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New LNP-based mRNA vaccine candidate protects against lethal SARS-CoV-2 in preclinical trials

New LNP-based mRNA vaccine candidate protects against lethal SARS-CoV-2 in preclinical trials
Even as over a score of vaccines against the coronavirus disease 2019 (COVID-19) pandemic have been rolled out following their emergence use authorization, others continue to be researched to fill the global need for effective deployment the world over.
A new study, published in
Nano Letters, describes an effective new vaccine candidate based on a messenger ribonucleic acid (mRNA) platform.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) attaches to host cells via its spike protein, causing the cell membrane to fuse with the virus to accomplish viral entry via endocytosis. The spike interacts with the host cell receptor, the human angiotensin-converting enzyme 2 (ACE2), at the receptor-binding domain (RBD), which forms the basis of the current vaccine candidate. ....

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New Direct-acting Antiviral Therapy With 99.9% Efficacy Against COVID-19 Developed

Covid-related Happy Hypoxia is a silent killer
Though the COVID-19 pandemic is in its second year, effective treatment against the SARS-CoV-2 virus remains elusive. The therapeutic regimens to manage the disease are directed towards symptomatic treatment. However, offering a potential weapon to take the virus head-on, a new study reports the development of an experimental antiviral therapy that attacks the virus s genome directly.
Developed by an international team of researchers, the therapy uses a novel lipid nanoparticle (LNP) delivery system and also utilizes a gene-silencing RNA technique known as siRNA (small-interfering RNA). The antiviral therapeutic was found to improve survival rates in mice and effective viral clearance in the survivors. ....

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Capricor Therapeutics Announces New Advances in Exosome-Mediated mRNA Delivery Platform

Capricor Therapeutics Announces New Advances in Exosome-Mediated mRNA Delivery Platform
-New Data Demonstrates Exosome-Mediated Delivery of mRNAs With Enhanced Expression and Lower Toxicity Compared to Lipid Nanoparticles-
-Functional Enzyme Expression and Real-Time Imaging of mRNA Expression in Live Animals-
-Platform for Advancing Clinical Development of Exosome-RNA Based Vaccine Candidate-
-Data to be Discussed on Earnings Call this Thursday, March 11 at 4:30 p.m. ET-
LOS ANGELES, March 09, 2021 (GLOBE NEWSWIRE) Capricor Therapeutics, Inc. (NASDAQ: CAPR), a biotechnology company focused on the development of transformative cell- and exosome-based therapeutics for the treatment and prevention of a broad spectrum of diseases, in collaboration with researchers, announced today that new advances from its positive preclinical study for a multivalent exosome-based mRNA vaccine for COVID-19 have been posted on the bioRxiv preprint server and has been submitted fo ....

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15 Fastest Growing Biotech Companies in the US

15 Fastest Growing Biotech Companies in the US
In this article we talk about 15 fastest growing biotech companies in the US. You can skip our detailed analysis of the biotech industry and go to 5 Fastest Growing Biotech Companies in the US.
Biotechnology is one of the most consequential domains of the healthcare industry. Biotechnology uses biology and the functions of living organisms to make new treatments and technology for healthcare. Advances in biotechnology are stepping stones for human progress in key areas like genetics, DNA sequencing, recombinant gene techniques, applied immunology and diagnostics. Data shows that global biotechnology market is expected to cross $720 billion in value by 2025. ....

United States , British Columbia , San Diego , United Kingdom , Nestudio Shutterstock , Bristol Myers Squibb , Abcellera Properties Inc , Abcellera Properties Columbia Inc , Zai Lab , Zai Lab Limited , Fastest Growing Biotech Companies , Intellia Therapeutics Inc , Fate Therapeutics Inc , Channel Biologics Pty Ltd , Humanigen Inc , Eli Lily Co , Equillium Inc , Juno Therapeutics Inc , Small Companies , Novavax Inc , Blueprint Medicines Corporation , Abcellera Us Holdings Inc , Abcellera Biologics Inc , Ultragenyx Pharmaceutical Inc , Lineage Biosciences Inc , Drug Administration ,

The global mRNA therapeutics and vaccines market is projected to be worth USD 10 billion in 2021, claims Roots Analysis

MRNA as a therapeutic / preventive agent has been demonstrated to be well tolerated & can harness the cell’s translational machinery to invoke immune responses ....

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