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SARS-CoV-2 B.1.617 mutations L452 and E484Q do not work together to evade antibodies


SARS-CoV-2 B.1.617 mutations L452 and E484Q do not work together to evade antibodies
A short report recently published in the
Journal of Infectious Diseases demonstrates how spike mutations L452R and E484Q found in the variant B.1.617.1 of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) each confer modestly diminished sensitivity to Pfizer-BioNTech (BNT162b2) mRNA vaccine-elicited antibodies – with combined mutations having a similar impact as either one of them alone.
Full global control of the coronavirus disease (COVID-19) pandemic has yet to be achieved, despite the fact that highly effective vaccines against its causative agent, SARS-CoV-2, are now at our disposal. This is partly due to the emergence of new viral variants with antibody escape mutations. ....

United Kingdom , Ravi Gupta , Cambridge Institute Of Therapeutic Immunology Infectious Disease , University Of Cambridge United Kingdom , Department Of Medicine , Infectious Diseases , Cambridge Institute , Therapeutic Immunology , Infectious Disease , ஒன்றுபட்டது கிஂக்டம் , ரவி குப்தா , கேம்பிரிட்ஜ் நிறுவனம் ஆஃப் சிகிச்சை நோயெதிர்ப்பு தொற்று நோய் , பல்கலைக்கழகம் ஆஃப் கேம்பிரிட்ஜ் ஒன்றுபட்டது கிஂக்டம் , துறை ஆஃப் மருந்து , தொற்று நோய்கள் , கேம்பிரிட்ஜ் நிறுவனம் , சிகிச்சை நோயெதிர்ப்பு , தொற்று நோய் ,

Study highlights risk of new SARS-CoV-2 mutations emerging during chronic infection


Study highlights risk of new SARS-CoV-2 mutations emerging during chronic infection
SARS-CoV-2 mutations similar to those in the B1.1.7 UK variant could arise in cases of chronic infection, where treatment over an extended period can provide the virus multiple opportunities to evolve, say scientists.
Given that both vaccines and therapeutics are aimed at the spike protein, which we saw mutate in our patient, our study raises the worrying possibility that the virus could mutate to outwit our vaccines
Ravi Gupta
Writing in
Nature, a team led by Cambridge researchers report how they were able to observe SARS-CoV-2 mutating in the case of an immunocompromised patient treated with convalescent plasma. In particular, they saw the emergence of a key mutation also seen in the new variant that led to the UK being forced once again into strict lockdown, though there is no suggestion that the variant originated from this patient. ....

United Kingdom , Ravi Gupta , National Institute Of Health Research , Cambridge Institute Of Therapeutic Immunology Infectious Disease , Genomics United Kingdom Consortium , Melinda Gates Foundation , Cambridge University Hospitals , Research Council , Cambridge Institute , Therapeutic Immunology , Infectious Disease , Medical Research Council , National Institute , Health Research , Melinda Gates , National Institute For Health Research Nihr , Bill And Melinda Gates Foundation , Wellcome Ravindra Gupta Coronavirus , Covid 19 , Infectious Diseases Covid 19 , Corona Virus , Infectious Diseases Cambridge Fights Covid , Cambridge Infectious Diseases , Cambridge Institute Of Therapeutic Immunology And Infectious Disease Citiid , Covid 19 Genomics Uk Cog Consortium , School Of Clinical Medicine ,

SARS-CoV-2 mutations risks during chronic infection - Outbreak News Today


Writing in 
Nature, a team led by Cambridge researchers report how they were able to observe SARS-CoV-2 mutating in the case of an immunocompromised patient treated with convalescent plasma. In particular, they saw the emergence of a key mutation also seen in the new variant that led to the UK being forced once again into strict lockdown, though there is no suggestion that the variant originated from this patient.
Image by Gerd Altmann from Pixabay
Using a synthetic version of the virus Spike protein created in the lab, the team showed that specific changes to its genetic code – the mutation seen in the B1.1.7 variant – made the virus twice as infectious on cells as the more common strain. ....

United Kingdom , Ravi Gupta , Cambridge Institute Of Therapeutic Immunology Infectious Disease , Genomics United Kingdom Consortium , Cambridge University Hospitals , Cambridge Institute , Therapeutic Immunology , Infectious Disease , ஒன்றுபட்டது கிஂக்டம் , ரவி குப்தா , கேம்பிரிட்ஜ் நிறுவனம் ஆஃப் சிகிச்சை நோயெதிர்ப்பு தொற்று நோய் , மரபியல் ஒன்றுபட்டது கிஂக்டம் கூட்டமைப்பு , கேம்பிரிட்ஜ் பல்கலைக்கழகம் மருத்துவமனைகள் , கேம்பிரிட்ஜ் நிறுவனம் , சிகிச்சை நோயெதிர்ப்பு , தொற்று நோய் ,