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Cryo-EM reveals Key Insight into Vital DNA repair process


Apr 24 2021 Read 4 Times
Scientists at the University of Glasgow have revealed key insights into a vital DNA repair process which is implicated in resistance to cancer treatments, using cryo-electron microscopy.
Led by the University of Glasgow the research(1) is based on data and models collected from the Scottish Centre for Macromolecular Imaging (SCMI) and was conducted with colleagues at the University of Dundee.
The study looks at a toxic type of DNA damage called inter-strand crosslinks, which is normally repaired through a process initiated by a single molecule of ubiquitin – a protein commonly found in humans, animals and plants – being attached to each of the affected strands of DNA. In order to complete the DNA repair process the ubiquitin molecule must also be successfully removed from the damaged site – a process known as deubiquitination. ....

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Stray bullet of jubilant soldiers kills mother of four on her farm in Imo


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Tragedy struck on Thursday evening along Owerri – Onitsha in Eziama Obiato Community in Mbaitoli Local Government Area of Imo State when one of the bullets fired by some jubilating soldiers at the army checkpoint at Ukwu Orji allegedly hit a woman in the community.
The 46-year-old mother of four and native of Umuagha village in Eziama Obiato community, Chikodi Ofoegbu, was said to be working in the farm when the bullet hit her.
According to a report by The Nation, the incident caused panic as youths were reportedly gearing for protests.
Eyewitnesses,  said the officers were jubilating safe return of one of their colleagues, who was thought to have been dead following the Easter Monday’s attack on the army checkpoint by gunmen. ....

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Editorial: More secrecy, governor?


Editorial: More secrecy, governor?
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THE ISSUE:
Gov. Andrew Cuomo has at least four law firms working on his behalf but won’t reveal how they’re being paid.
THE STAKES:

Gov. Andrew Cuomo has an ever-growing need for lawyers.
New evidence of that arrived Monday, when we learned state Attorney General Letitia James, acting on a referral from Comptroller Thomas DiNapoli, will be investigating the governor’s possibly criminal use of state employees for his coronavirus book the one he got a huge but still secret advance for.
In turn, Richard Azzopardi, a spokesman for Mr. Cuomo, claimed Mr. DiNapoli and Ms. James, both Democrats, are considering running for governor and alleged the investigation was really about their wanting to “further political self-interest.” ....

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Acorns Vs. Stash: Which Investing App Is Better for You?


ETF portfolios are tailored to your risk tolerance and investment goals
Automated custodial investment accounts for kids
 
You can t invest in specific companies; Acorns assigns and manages your portfolio for you
If you don t invest regularly, monthly fees could be high compared to other automated advisors like SoFi
 
Acorns is an automated investing app offering personal investment accounts, IRAs,
checking accounts
, and investment accounts for kids. While the investment platform has a $0 account minimum, you ll need at least $5 to start investing. 
As for fees, Acorns offers three plans at various price points: Acorns Lite, Acorns Personal, and Acorns Family. If you re solely interested in investing with a personal investment account, Acorns Lite might be best for you. The account has a $1 monthly fee, but it: (a) invests your money in an ETF portfolio tailored toward your risk toleranc ....

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Hardwiring dash cam - JeepForum.com


Hardwiring dash cam
Rear Axle: Dana 44 Yukon Zip Locker
Axle Gear Ratio: 4.88
Tires: 315/70-17 Duratracs
Recovery: Warn 9.5ti winch
Accessories: sound system, tuffy security
Hardwiring dash cam
After the recent incident of me getting run off the road and breaking a finger in the steering wheel as I jumped a high curb, I decided to get a dash cam.
First and foremost, I want a clean installation, hence not simply plugging it into the cigarette lighter. Yes, this will be in my 2014 JKU Sahara.
I have already picked two top contenders as far as cameras, but I am researching the installation prior to purchase. It is so mole enough that even my old useless should be able to do it. ....

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