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COVID: German scientists may know how to prevent vaccine blood clots

Scientists in Germany believe they may have worked out a way to prevent vector-based vaccines from causing rare blood clots. ....

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How worried should we be about blood clots linked to AstraZeneca, J&J vaccines?

ZURICH/FRANKFURT/LONDON/CHICAGO (May 27): International drug regulators have said the benefits of using Covid-19 vaccines developed by Johnson & Johnson and AstraZeneca outweigh risks as they investigate reports of extremely rare, but potentially fatal blood clots. ....

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COVID: German scientists may know how to prevent vaccine blood clots | Science| In-depth reporting on science and technology | DW

Concerns over AstraZeneca vaccine
How it works
It starts with the delivery of the gene for the Sars-CoV-2 spike protein. In vector-based vaccines, this is delivered via an adenoviral system, the scientists write.
The SARS-CoV-2 spike gene is then transcribed inside of the nucleus and subsequently exported as mRNA out of the nucleus. Arriving in the cytosol, the mRNA is again translated into the Spike protein.
And exactly here lies the problem, the scientists write, the viral piece of DNA deriving from an RNA virus is not optimized to be transcribed inside of the nucleus.
In the nucleus, splicing of the spike protein can occur at splice sites. ....

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