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Customized Adjuvant Chemo Falls Short in Early Lung Cancer


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A pharmacogenomic-driven approach for adjuvant chemotherapy in early-stage non-small cell lung cancer (NSCLC) significantly reduced treatment-related toxicity but failed to improve survival in the international, phase III ITACA trial.
Among nearly 800 patients with stage II-IIIA disease who achieved a complete resection, median overall survival (OS) reached 96.4 months in the tailored chemotherapy arm versus 83.5 months with a standard cisplatin-based doublet (HR 0.76, 95% CI 0.55-1.04), reported Silvia Novello, MD, PhD, of the University of Torino at San Luigi Gonzaga Hospital in Italy.
Recurrence-free survival (RFS) reached 64.4 months in the tailored arm, where patients received one of four different treatments based on their mRNA expression levels of excision repair cross complementation 1 (ERCC1) and thymidylate synthase (TS), as compared with 41.5 months in the control arm (HR 0.94, 95% CI 0.74-1.20). ....

Silvia Novello , Ian Ingram , International Tailored Chemotherapy Adjuvant , San Luigi Gonzaga Hospital , World Conference , Medpage Today , Deputy Managing Editor , சில்வியா நாவல் , ஈயந் இஂக்ரம் , சான் லூயிஜி கந்ஸாய மருத்துவமனை , உலகம் மாநாடு , துணை நிர்வகித்தல் ஆசிரியர் ,

Phase III study of (m)RNA expression did not confer significant advantage for stage II-III lung cancer


Phase III study of (m)RNA expression did not confer significant advantage for stage II-III lung cancer
A phase III study examining whether messenger (m)RNA expression correlated with sensitivity or resistance to chemotherapy did not confer a statistically significant advantage in overall survival for patients with resected stage II-III non-small cell lung cancer (NSCLC), according to research presented at the International Association for the Study of Lung Cancer World Conference on Lung Cancer.
Lung cancer researchers and clinicians have sought methods to improve chemotherapy s modest 5% overall survival rate for patients with NSCLC. Dr. Silvia Novello, professor of medical oncology at the University of Torino at San Luigi Gonzaga Hospital, Orbassano, Italy, and a large group of European researchers evaluated the predictive utility of the mRNA expression levels of molecular markers, mRNA expression levels of molecular markers, excision repair cross-complementing group ERC ....

Silvia Novello , Tetsuya Mitsudomi , Emily Henderson , University Of Torino , International Association , Lung Cancer World Conference , San Luigi Gonzaga Hospital , Medical Oncology , Lung Cancer , Non Small Cell Lung Cancer , Small Cell Lung Cancer , சில்வியா நாவல் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் டொரினோ , சர்வதேச சங்கம் , நுரையீரல் புற்றுநோய் உலகம் மாநாடு , சான் லூயிஜி கந்ஸாய மருத்துவமனை , மருத்துவ புற்றுநோயியல் , நுரையீரல் புற்றுநோய் , அல்லாத சிறிய செல் நுரையீரல் புற்றுநோய் , சிறிய செல் நுரையீரல் புற்றுநோய் , அறுவை சிகிச்சை ,

Selected gene mRNA expression is not predictive of improved overall survival


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(Singapore January 30, 2021 11:00 p.m. SPT/January 30, 2021 10:00 a.m. EST) A phase III study examining whether messenger (m)RNA expression correlated with sensitivity or resistance to chemotherapy did not confer a statistically significant advantage in overall survival for patients with resected stage II-III non-small cell lung cancer (NSCLC), according to research presented at the International Association for the Study of Lung Cancer World Conference on Lung Cancer.
Lung cancer researchers and clinicians have sought methods to improve chemotherapy s modest 5% overall survival rate for patients with NSCLC. Dr. Silvia Novello, professor of medical oncology at the University of Torino at San Luigi Gonzaga Hospital, Orbassano, Italy, and a large group of European researchers evaluated the predictive utility of the mRNA expression levels of molecular markers, mRNA expression levels of molecular markers, excision repair cross-complementing group ERCC1 and thymidyla ....

Silvia Novello , Tetsuya Mitsudomi , International Association , Lung Cancer World Conference , San Luigi Gonzaga Hospital , Lung Cancer , Thoracic Oncology , சில்வியா நாவல் , சர்வதேச சங்கம் , நுரையீரல் புற்றுநோய் உலகம் மாநாடு , சான் லூயிஜி கந்ஸாய மருத்துவமனை , நுரையீரல் புற்றுநோய் , தொராசி புற்றுநோயியல் ,

IASLC hosts 2020 World Conference on Lung Cancer Singapore


The 2020 WCLC Presidential Symposium features:
National Lung Cancer Screening Program in Taiwan: The TALENT Study (Abstract 3309), Pan-Chyr Yang, M.D., from the National Taiwan University College of Medicine, Taipei/Taiwan.
International Tailored Chemotherapy Adjuvant Trial: ITACA (Abstract 1820) with Dr. Silvio Novello, University of Torino at San Luigi Gonzaga Hospital, Orbassano, Italy.
Surgical and Clinical Outcomes with Neoadjuvant Atezolizumab in Resectable Stage IB-IIIB NSCLC: LCMC3 Trial Primary Analysis (Abstract 3195) with Jay M. Lee, M.D., Ronald Reagan UCLA Medical Center in Los Angeles.
Registrational Phase 2 Trial of Sotorasib in Kras P. G12C Mutant NSCLC: First Disclosure of the CodeBreak100 Primary Analysis (Abstract 3037) with Bob Li, M.D., Memorial Sloan Kettering Cancer Center in New York City. ....

New York , United States , Memorial Sloan Kettering Cancer Center , New South Wales , United Kingdom , T Ai Pei , The University Of Sydney , Neoadjuvant Atezolizumab , Michael Boyer , Bob Li , Los Angeles , Pan Chyr Yang , Jaym Lee , Chris Obrien Lifehouse , Silvio Novello , University Of Leicester , International Tailored Chemotherapy Adjuvant Trial , National Lung Cancer Screening Program , National Taiwan University College Of Medicine , International Association , Lung Cancer Hosts , Lung Cancer Singapore January , Lung Cancer , Lung Cancer Screening Program , National Taiwan University College , San Luigi Gonzaga Hospital ,