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New Hope for Previously 'Undruggable' Non-Small-Cell Lung Cancer


Seksan Mongkhonkhamsao/Getty Images
Over the course of the last 15 years, the discovery that some lung cancers are driven by gene mutations that can be targeted with drugs has dramatically increased survival time for many patients. However, one identified mutation, to the KRAS gene, has eluded effective drugs.
Data from a phase 2 trial presented at the conference showed that, of 126 patients with non-small-cell lung cancer and a KRAS mutation treated with the experimental cancer drug sotorasib, 37.1 percent responded.
The average progression-free survival for all patients in the trial (the length of time in which the tumor did not grow) was 6.8 months. For patients who responded to the drug, the duration of the response lasted on average for 10 months. ....

New York , United States , Memorial Sloan Kettering Cancer Center , Bob Li , Drug Administration , University Of California San Francisco , International Association , Lung Cancer World Conference , New York City , California San Francisco , புதியது யார்க் , ஒன்றுபட்டது மாநிலங்களில் , நினைவகம் ஸ்லோன் கெட்டரிங் புற்றுநோய் மையம் , பாப் லி , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா சான் பிரான்சிஸ்கோ , சர்வதேச சங்கம் , நுரையீரல் புற்றுநோய் உலகம் மாநாடு , புதியது யார்க் நகரம் , கலிஃபோர்னியா சான் பிரான்சிஸ்கோ ,

Nivolumab Found Effective to Treat Malignant Mesothelioma


Nivolumab Found Effective to Treat Malignant Mesothelioma
by Angela Mohan on 
February 1, 2021 at 12:18 PM
Nivolumab found effective for relapsed malignant mesothelioma (MM), according to research presented at the International Association for the Study of Lung Cancer World Conference on Lung Cancer.
Malignant mesothelioma is an intractable cancer, and no phase III trial has yet shown an improvement in overall survival following the standard first line chemotherapy doublet comprising pemetrexed and cisplatin or carboplatin since it was licensed in 2004.
Professor Dean Fennell, chair of Thoracic Medical Oncology at the University of Leicester in collaboration with Professor Gareth Griffiths and his team at the Southampton Clinical Trials Unit, University of Southampton, UK, presented results of the Checkpoint Blockade for Inhibition of Relapsed Mesothelioma (CONFIRM) study, funded by Cancer Research UK/Stand Up To Cancer. ....

International Association , Lung Cancer World Conference , Lung Cancer , Malignant Mesothelioma , Intractable Cancer , Programmed Death 1 Pd Inhibitor , சர்வதேச சங்கம் , நுரையீரல் புற்றுநோய் உலகம் மாநாடு , நுரையீரல் புற்றுநோய் , வீரியம் மிக்கது மீசோதெலியோமா , ப்ரோக்ராம்ட் இறப்பு பி.டி. தடுப்பான் ,

Phase III study of (m)RNA expression did not confer significant advantage for stage II-III lung cancer


Phase III study of (m)RNA expression did not confer significant advantage for stage II-III lung cancer
A phase III study examining whether messenger (m)RNA expression correlated with sensitivity or resistance to chemotherapy did not confer a statistically significant advantage in overall survival for patients with resected stage II-III non-small cell lung cancer (NSCLC), according to research presented at the International Association for the Study of Lung Cancer World Conference on Lung Cancer.
Lung cancer researchers and clinicians have sought methods to improve chemotherapy s modest 5% overall survival rate for patients with NSCLC. Dr. Silvia Novello, professor of medical oncology at the University of Torino at San Luigi Gonzaga Hospital, Orbassano, Italy, and a large group of European researchers evaluated the predictive utility of the mRNA expression levels of molecular markers, mRNA expression levels of molecular markers, excision repair cross-complementing group ERC ....

Silvia Novello , Tetsuya Mitsudomi , Emily Henderson , University Of Torino , International Association , Lung Cancer World Conference , San Luigi Gonzaga Hospital , Medical Oncology , Lung Cancer , Non Small Cell Lung Cancer , Small Cell Lung Cancer , சில்வியா நாவல் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் டொரினோ , சர்வதேச சங்கம் , நுரையீரல் புற்றுநோய் உலகம் மாநாடு , சான் லூயிஜி கந்ஸாய மருத்துவமனை , மருத்துவ புற்றுநோயியல் , நுரையீரல் புற்றுநோய் , அல்லாத சிறிய செல் நுரையீரல் புற்றுநோய் , சிறிய செல் நுரையீரல் புற்றுநோய் , அறுவை சிகிச்சை ,

Selected gene mRNA expression is not predictive of improved overall survival


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(Singapore January 30, 2021 11:00 p.m. SPT/January 30, 2021 10:00 a.m. EST) A phase III study examining whether messenger (m)RNA expression correlated with sensitivity or resistance to chemotherapy did not confer a statistically significant advantage in overall survival for patients with resected stage II-III non-small cell lung cancer (NSCLC), according to research presented at the International Association for the Study of Lung Cancer World Conference on Lung Cancer.
Lung cancer researchers and clinicians have sought methods to improve chemotherapy s modest 5% overall survival rate for patients with NSCLC. Dr. Silvia Novello, professor of medical oncology at the University of Torino at San Luigi Gonzaga Hospital, Orbassano, Italy, and a large group of European researchers evaluated the predictive utility of the mRNA expression levels of molecular markers, mRNA expression levels of molecular markers, excision repair cross-complementing group ERCC1 and thymidyla ....

Silvia Novello , Tetsuya Mitsudomi , International Association , Lung Cancer World Conference , San Luigi Gonzaga Hospital , Lung Cancer , Thoracic Oncology , சில்வியா நாவல் , சர்வதேச சங்கம் , நுரையீரல் புற்றுநோய் உலகம் மாநாடு , சான் லூயிஜி கந்ஸாய மருத்துவமனை , நுரையீரல் புற்றுநோய் , தொராசி புற்றுநோயியல் ,

Nivolumab effective treatment for malignant mesothelioma


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(Singapore January 30, 2021 11:00 p.m. SPT/January 30, 2021 10:00 a.m. EST) Nivolumab monotherapy is an effective treatment option for relapsed malignant mesothelioma (MM), according to research presented today at the International Association for the Study of Lung Cancer World Conference on Lung Cancer.
Malignant mesothelioma is an intractable cancer, and no phase III trial has yet shown an improvement in overall survival following the standard first line chemotherapy doublet comprising pemetrexed and cisplatin or carboplatin since it was licensed in 2004.
Professor Dean Fennell, chair of Thoracic Medical Oncology at the University of Leicester in collaboration with Professor Gareth Griffiths and his team at the Southampton Clinical Trials Unit, University of Southampton, UK, presented results of the Checkpoint Blockade for Inhibition of Relapsed Mesothelioma (CONFIRM) study, funded by Cancer Research UK/Stand Up To Cancer. The investigator-led, placebo-cont ....

United Kingdom , Gareth Griffiths , Giorgio Scagliotti , University Of Leicester , University Of Southampton , Eastern Cooperative Oncology Group , International Association , Lung Cancer World Conference , Dean Fennell , Thoracic Medical Oncology , Professor Gareth Griffiths , Southampton Clinical Trials Unit , Checkpoint Blockade , Relapsed Mesothelioma , Cancer Research United , Lung Cancer , Thoracic Oncology , ஒன்றுபட்டது கிஂக்டம் , கரேத் கிரிஃபித்ஸ் , பல்கலைக்கழகம் ஆஃப் லெய்செஸ்டர் , பல்கலைக்கழகம் ஆஃப் சவுத்தாம்ப்டன் , கிழக்கு கூட்டுறவு புற்றுநோயியல் குழு , சர்வதேச சங்கம் , நுரையீரல் புற்றுநோய் உலகம் மாநாடு , டீன் ஃபெநல் , தொராசி மருத்துவ புற்றுநோயியல் ,