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Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes

Most analyses of the antibody responses induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have focused on antibodies cloned from memory B cells. This approach has led researchers to conclude that neutralizing antibodies (nAbs) primarily target the receptor-binding domain (RBD) of the virus s spike protein. Voss et al. took a different approach, using proteomic deconvolution of the serum immunoglobulin G antibody repertoire from four COVID-19 convalescent patients. They found that the nAb response was largely directed against epitopes such as the N-terminal domain (NTD), which lie outside the RBD. Several of these nAbs were shared among donors and targeted an NTD epitope that is frequently mutated by variants of concern.

Science , abg5268, this issue p. [1108][1]

The molecular composition and binding epitopes of the immunoglobulin G (IgG) antibodies that circulate in blood plasma after severe acute respiratory syndrome coronavirus 2 (SARS-Co ....

United States , San Francisco , University Of California , Lamontagne Center , Ut System Proteomics Network , National Institute Of Allergy , Department Of Defense , Infectious Diseases Research Program , Sauer Structural Biology Laboratory , Us Army , Research Institute Of Texas , University Of Texas Board Regents , Centers For Disease , National Institutes Of Health , Electron Microscopy Data Bank , Department Of The Army , Welch Foundation , Protein Data Bank , University Of Texas College Natural Sciences , Clayton Foundation , Ig Seq Lin , United Kingdom , Creative Commons Attribution , Infectious Disease , Military Infectious Diseases Research Program , Disease Control ,

How UT Research Led to the Development of the COVID-19 Vaccine in Record-Breaking Time

Jason McLellan in his lab on January 18, 2021.
Credit: Matt Wright-Steel
On January 6, 2020, Jason McLellan and his wife, Jinelle, were in Park City, Utah, for their family’s first-ever snowboarding vacation. It was a chance for the couple and their two young kids to relax after the holidays and before the spring semester kicked off at UT, when McLellan would begin his second year as an associate professor in molecular biosciences. 
McLellan’s new snowboarding boots were pinching him, so he stopped at a shop to get them heat-molded to his feet. While he waited, McLellan saw Barney Graham’s name flash across his phone. The pair had first met in 2008 at the National Institutes of Health (NIH), where Graham is deputy director of the National Institute of Allergy and Infectious Diseases’ Vaccine Research Center, and McLellan was conducting his postdoctoral research in structure-based vaccine design after receiving his PhD from Johns Hopkins. ....

United States , New York , Johns Hopkins University , National Institutes Of Health , Wayne State University , Park City , University Of Texas , New Yorker , Betsy Sauer , Vivian Abigui , Barney Graham , Katie Friel , Lawrence Wright , Jason Mclellan , Paul Goldbart , Matt Wright , Johns Hopkins , Nianshuang Wang , Daniel Leahy , Daniel Wrapp , Dartmouth College , Sauer Lab , National Institute Of Allergy , Technology Acquisition , Cancer Prevention Research Institute Of Texas , College Of Natural Sciences ,