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Topical delivery of Levocarnitine for Dry Eye Disease


Discussion
New technologies have been explored in many researches such as a kind of long-acting mucoadhesive thermogels and gallate-loaded gelatin-g-poly (N-Isopropylacrylamide) for the treatment of DED. As the first recommended drug in “Dry Eye Diagnosis and Treatment Guidelines”, the protective effect of LC on corneal epithelial cells under hypertonic state has been verified.
22–24 Another research group prepared an artificial formulation which also used LC as a part of formulation to help replenish the tear film.
25 In this study, a kind of thermosensitive in situ gel of LC was prepared which is in a floating condition at room temperature while can form a gel rapidly as soon as dropped in the ocular surface of rabbits. The mechanism of the gelatinization under specific temperature of LCTG was relevant with hydrophobic effect of groups, hydrogen-bond interaction among polymer chains and hydrogen-bond interaction among hydrophilic group. On the one hand, LCTG ca ....

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[Full text] Schisandrin Inhibits NLRP1 Inflammasome-Mediated Neuronal Pyroptosis i


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1Department of Organs, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040, Heilongjiang, People’s Republic of China;
2Teaching and Research Department of Basic Theory of Traditional Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin 150040, Heilongjiang, People’s Republic of China;
3Teaching and Research Department of Diagnostics of Traditional Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin 150040, Heilongjiang, People’s Republic of China;
4Department of Cardiovascular Diseases, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040, Heilongjiang, People’s Republic of China
Correspondence: Li Liu
Department of Cardiovascular Diseases, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, No. 26 Heping Road, Xiangfang District, Harbin 150040, Heilongjiang, People’s Republic of China ....

Grand Island , United States , United Kingdom , Dbo Mmjax , Leica Microsystems , Beyotime Haimen , Spss Inc , Drug Administration , Model Animal Research Center , Standard Medical Laboratory Animal Care , Heilongjiang University Of Chinese Medicine No , Protocols Ministry Of Health Pr China , Sunny Instruments Co , Sigma Company Ltd , Weikeqi Biological Technology Company Ltd , Nanjing University , First Affiliated Hospital , Heilongjiang University , Chinese Medicine , Use Protocols , Laboratory Animal Ethical Standards , Weikeqi Biological Technology Company , Morris Water Maze , Beijing Sunny Instruments , Abeta Amyloid , Situ Cell Death Detection Kit ,