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First synthetic circuit consists of entirely fast, reversible protein-protein interactions


First synthetic circuit consists of entirely fast, reversible protein-protein interactions
Synthetic biology offers a way to engineer cells to perform novel functions, such as glowing with fluorescent light when they detect a certain chemical. Usually, this is done by altering cells so they express genes that can be triggered by a certain input.
However, there is often a long lag time between an event such as detecting a molecule and the resulting output, because of the time required for cells to transcribe and translate the necessary genes. MIT synthetic biologists have now developed an alternative approach to designing such circuits, which relies exclusively on fast, reversible protein-protein interactions. ....

Bonnie Berger , Brian Teague , Ron Weiss , Tristan Bepler , Deepak Mishra , Emily Henderson , University Of Wisconsin , Artificial Intelligence Laboratory , Department Of Biological Engineering , Department Of Biochemistry , Study Lead Author , Research Associate , Biological Engineering , Simons Professor , Jim Broach , Molecular Biology , Penn State Hershey Medical , போனி பெர்கர் , பிரையன் டீக் , ரோன் வெயிஸ் , தீபக் மிஸ்ரா , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் விஸ்கான்சின் , செயற்கை உளவுத்துறை ஆய்வகம் , துறை ஆஃப் உயிரியல் பொறியியல் , துறை ஆஃப் உயிர் வேதியியல் ,

Synthetic biology circuits can respond within seconds


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Synthetic biology offers a way to engineer cells to perform novel functions, such as glowing with fluorescent light when they detect a certain chemical. Usually, this is done by altering cells so they express genes that can be triggered by a certain input.
 
However, there is often a long lag time between an event such as detecting a molecule and the resulting output, because of the time required for cells to transcribe and translate the necessary genes. MIT synthetic biologists have now developed an alternative approach to designing such circuits, which relies exclusively on fast, reversible protein-protein interactions. This means that there’s no waiting for genes to be transcribed or translated into proteins, so circuits can be turned on much faster within seconds. ....

Bonnie Berger , Brian Teague , Ron Weiss , Tristan Bepler , Deepak Mishra , National Science Foundation Graduate Research Fellowship Program , Artificial Intelligence Laboratory , Department Of Biological Engineering , Institute For Collaborative Biotechnologies , National Institutes Of Health , National Science Foundation , Department Of Biochemistry , University Of Wisconsin , Us Army Research Office , Energy Research Fellowship , Biological Engineering , Simons Professor , Jim Broach , Molecular Biology , Penn State Hershey Medical , Siebel Scholars Award , Research Fellowship , Collaborative Biotechnologies , Research Office , Integrated Synthetic Biology , National Institutes ,

Eight from MIT named 2021 Sloan Research Fellows


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The Alfred P. Sloan Foundation announced Feb. 16 that it has awarded Sloan Research Fellowships to eight MIT professors in the MIT Media Lab and in the departments of Biology, Brain and Cognitive Sciences, Chemical Engineering, Electrical Engineering and Computer Science, and Mathematics. The fellowships, which honor pre-tenure faculty members, will support their research with two-year, $75,000 awards.
“The Sloan Research Fellowship Program recognizes and rewards outstanding early-career faculty who have the potential to revolutionize their fields of study,” according to the Sloan Foundation.
Fadel Adib, associate professor and Doherty Chair in Ocean Utilization, directs the Signal Kinetics group at the MIT Media Lab. His group invents, builds, and deploys wireless and sensor technologies to address complex problems in society, industry, and ecology. His team’s work focuses on bringing wireless capabilities to extreme domains like ....

United States , Karthish Manthiram , Joseph Joey Davis , Steven Flavell , Lisa Piccirillo , Bonnie Berger , Heather Kulik , Luquiao Liu , John Conway , Fadel Adib , Sloan Research Fellowship Program , Breakthrough Foundation , Alfredp Sloan Foundation , Cognitive Sciences , Department Of Electrical Engineering , Picower Institute For , Sloan Foundation , Sloan Research Fellowships , Theodoret Miller Career Development , Whitehead Career Development Assistant Professor In Biology , Media Lab , Sloan Research Fellowship , Chemical Engineering , Electrical Engineering , Computer Science , Doherty Chair ,