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Point of View: Open science takes on Parkinson's disease


Abstract
The Aligning Science Across Parkinson’s (ASAP) initiative was set up to improve understanding of the biology underlying the onset and progression of Parkinson’s disease. With an emphasis on open science and collaboration, we have assembled a research network led by nearly 100 investigators to explore the pathology of Parkinson’s disease, and this network will soon expand to include researchers working on relevant (dys)-functional neural circuits. We have also contributed to large-scale genetics and patient cohort initiatives related to the disease. We hope that these actions, and others planned for the future, will deepen our knowledge of the molecular mechanisms underlying the origin and evolution of Parkinson’s disease and, ultimately, contribute to the development of novel therapies. ....

United States , Shalini Padmanabhan , Chevy Chase , Todd Sherer , Michelle Durborow , Maggie Kuhl , Alyssa Reimer , Randy Schekman , University Of California , Parkinson Progression Markers Initiative , Global Parkinson Genetics Program , Medicines Partnership For Parkinson , Melinda Gates Foundation , Sergey Brin Family Foundation , Andrew Singleton National Institutes Of Health , Cure Parkinson , Planning Advisory Council , Collaborative Research Network , Parkinson Foundation , Department Of Molecular , Michaelj Fox Foundation For Parkinson Research , Kenneth Marek Institute For Neurodegenerative Disorders , Howard Hughes Medical Institute , Aligning Science Across Parkinson , Show Parkinson , Planning Advisory ,

Building a Genetic Map for Parkinson's Labmate Online


Jan 08 2021 Read 502 Times
A team from the Francis Crick Institute, UCL and Cambridge University has been awarded $7.7million to identify the genetic and biological factors that cause Parkinson’s disease.
The team, co-led by Sonia Gandhi, Group Leader of the Crick’s Neurodegeneration Biology laboratory, has received the grant from ASAP (Aligning Science Across Parkinson’s). This global research initiative funds teams that are working on understanding the basic mechanisms that contribute to the development and progression of Parkinson’s disease.
By using advanced imaging methods to look for single molecules, or oligomers, in the brain as indicators of early onset of the disease, the researchers aim to build a map of the cells first affected and the conditions progression. By looking at all the genes expressed in those specific cells, they will build a model that shows how genetic factors affect pathways that cause Parkinson’s. The aim is to then modif ....

United Kingdom , Nicholas Wood , Sonia Gandhi , Cambridge University , Group Leader Of The Crick , Queen Square Institute Of Neurology , Francis Crick Institute , Group Leader , Neurodegeneration Biology , Aligning Science Across Parkinson , Square Institute , ஒன்றுபட்டது கிஂக்டம் , நிக்கோலஸ் மரம் , சோனியா காந்தி , கேம்பிரிட்ஜ் பல்கலைக்கழகம் , குழு தலைவர் ஆஃப் தி கிரிக் , ராணி சதுரம் நிறுவனம் ஆஃப் நரம்பியல் , பிரான்சிஸ் கிரிக் நிறுவனம் , குழு தலைவர் , சீரமைத்தல் அறிவியல் குறுக்கே பார்கின்சன் , சதுரம் நிறுவனம் ,