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Gerald Wogan, professor emeritus of biological engineering, chemistry, and toxicology, dies at 91

Gerald Wogan, professor emeritus of biological engineering, chemistry, and toxicology, dies at 91
mit.edu - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from mit.edu Daily Mail and Mail on Sunday newspapers.

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Study: One enzyme dictates cells' response to a probable carcinogen

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CAMBRIDGE, MA In the past few years, several medications have been found to be contaminated with NDMA, a probable carcinogen. This chemical, which has also been found at Superfund sites and in some cases has spread to drinking water supplies, causes DNA damage that can lead to cancer.
MIT researchers have now discovered a mechanism that helps explain whether this damage will lead to cancer in mice: The key is the way cellular DNA repair systems respond. The team found that too little activity of one enzyme necessary for DNA repair leads to much higher cancer rates, while too much activity can produce tissue damage, especially in the liver, which can be fatal. ....

United States , United Kingdom , Stephen Dertinger , Dushan Wadduwage , Dorothea Torous , Ilana Nazari , Jennifer Kay , Ishwar Kohale , Bevin Engelward , John Essigmann , Leona Samson , Svetlana Avlasevich , Amanda Armijo , Robert Croy , Sebastian Carrasco , Joshua Corrigan , National Cancer Institute , National Institute Of Environmental Health Sciences , Environmental Health Sciences , National Institute , Olin Chemical , Environmental Health , Advanced Imaging , Litron Laboratories , Forest White , Biomedical Environmental Chemical Engineering ,

Study: One enzyme dictates cells' response to a probable carcinogen | MIT News | Massachusetts Institute of Technology

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In the past few years, several medications have been found to be contaminated with NDMA, a probable carcinogen. This chemical, which has also been found at Superfund sites and in some cases has spread to drinking water supplies, causes DNA damage that can lead to cancer.
MIT researchers have now discovered a mechanism that helps explain whether this damage will lead to cancer in mice: The key is the way cellular DNA repair systems respond. The team found that too little activity of one enzyme necessary for DNA repair leads to much higher cancer rates, while too much activity can produce tissue damage, especially in the liver, which can be fatal. ....

United States , Harvard University , Stephen Dertinger , Dushan Wadduwage , Dorothea Torous , Ilana Nazari , Jennifer Kay , Ishwar Kohale , Bevin Engelward , John Essigmann , Leona Samson , Svetlana Avlasevich , Amanda Armijo , Robert Croy , Sebastian Carrasco , Joshua Corrigan , National Cancer Institute , National Institute Of Environmental Health Sciences , Environmental Health Sciences , Imaging At Harvard University , National Institute , Olin Chemical , Environmental Health , Advanced Imaging , Litron Laboratories , Forest White ,

Designing in a pandemic to fight a pandemic

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Image: Sean Clarke
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Last fall, seniors in the MIT Department of Biological Engineering (BE) took on the most relevant of all possible design challenges the Covid-19 pandemic. The capstone design class in the Course 20 major, class 20.380 (Biological Engineering Design) has a different theme every semester, and in September there was little doubt about this fall’s topic Addressing the Pandemic with BE. “We weren t sure how students would respond. Would they be exhausted by Covid? Instead, students leapt at the chance to apply their skills to such an immediate problem,” says Professor Angela Koehler, a member of the teaching team. ....

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