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Interaction between LDL cholesterol and PRS can predict risk of heart attack


Interaction between LDL cholesterol and PRS can predict risk of heart attack
Allelica, a leading genomics software company specializing in developing polygenic risk scores (PRS) for personalized medicine, today announced publication of a study in
Circulation (Vol. 143, Issue 10) showing that the effect of LDL cholesterol on a person s risk of having a heart attack depends on their genes.
Using Allelica s proprietary PRS analysis software, the data showed that combining information on an individual s genetic risk of heart attack with their LDL level helps determine those at most risk from heart attack, including those potentially in need of treatment with statins or PCSK9 inhibitors. ....

Giordano Bott , George Busby , Emily Henderson , Coronary Artery Disease , United Kingdom , Heart Attack , ஜியோர்டானோ பாட்டில் , ஜார்ஜ் பஸ்பி , எமிலி ஹென்டர்சன் , கரோனரி தமனி நோய் , ஒன்றுபட்டது கிஂக்டம் , இதயம் தாக்குதல் ,

Researchers identify human BCAS3 and C16orf70 as novel autophagic proteins


Researchers identify human BCAS3 and C16orf70 as novel autophagic proteins
Autophagy is an intracellular degradation process of cytosolic materials and damaged organelles. Researchers at Ubiquitin Project of TMIMS have been studying the molecular mechanism of mitophagy, the selective autophagy process to eliminate damaged mitochondria. PINK1 (a serine/threonine kinase) and Parkin (a ubiquitin ligating enzyme: E3) work together to ubiquitylate the outer membrane proteins of damaged mitochondria, then ubiquitin chains are recognized as signals for autophagy degradation. Dysfunction of mitophagy causes a decrease in mitochondrial quality with overproduction of ROS, and is linked to neurodegenerative diseases like Parkinson s disease. ....

Emily Henderson , Ubiquitin Project , Breast Carcinoma Amplified Sequence , Drug Discovery , Life Science , Neurodegenerative Diseases , Parkinson 39s Disease , எமிலி ஹென்டர்சன் , மார்பக புற்றுநோய் பெருக்கப்பட்டது வரிசை , மருந்து கண்டுபிடிப்பு , வாழ்க்கை அறிவியல் ,

Researchers decipher how interspecies interactions arise, evolve and are maintained


Researchers decipher how interspecies interactions arise, evolve and are maintained
Interspecies interactions are the foundation of ecosystems, from soil to ocean to the human gut. Among the many different types of interactions, syntrophy is a particularly important and mutually beneficial interspecies interaction where one partner provides a chemical or nutrient that is consumed by the other in exchange for a reward.
Syntrophy plays an essential role in global carbon cycles by mediating the conversion of organic matter to methane, which is about 30 times more potent than carbon dioxide as a greenhouse gas and is a source of sustainable energy. And in the human gut, trillions of microbial cells also interact with each other and other species to modulate the physiology of their human host. ....

Nitin Baliga , Serdar Turkarslan , Emily Henderson , Baliga Lab , Study Co , Institute For Systems Biology , Study Co Corresponding Author , Senior Vice President , நிடின் பலிகா , எமிலி ஹென்டர்சன் , பலிகா ஆய்வகம் , படிப்பு இணை , நிறுவனம் க்கு அமைப்புகள் உயிரியல் , மூத்தவர் துணை ப்ரெஸிடெஂட் ,