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Bristol Myers Squibb Receives Positive CHMP Opinion for Onureg® as Frontline Oral Maintenance Therapy for Adults with Acute Myeloid Leukemia in First Remission


If approved, Onureg will become the first and only once daily oral frontline maintenance therapy in Europe for patients with a broad range of acute myeloid leukemia subtypes In the pivotal QUAZAR ® AML-001 study, Onureg demonstrated significant overall survival and showed a relapse-free survival benefit in patients with AML in first remission Bristol Myers Squibb today announced the Committee for Medicinal Products …
If approved, Onureg will become the first and only once daily oral frontline maintenance therapy in Europe for patients with a broad range of acute myeloid leukemia (AML) subtypes
In the pivotal QUAZAR
® AML-001 study, Onureg demonstrated significant overall survival and showed a relapse-free survival benefit in patients with AML in first remission ....

United States , United Kingdom , Nina Goworek , Noah Berkowitz , Bristol Myers Squibb , Hematology Development , European Commission , Bristol Myers Squibb Company , Exchange Commission , European Union , European Medicines Agency , Committee For Medicinal Products Human Use , American Cancer Society , Myers Squibb , Medicinal Products , Human Use , Bristol Myers , Centralized Marketing Authorization , Great Britain , Early Mortality , Myelodysplastic Syndromes , Fetal Toxicity , Prescribing Information , Better Future , Juno Therapeutics , Private Securities Litigation Reform Act ,

Big data analysis finds cancer's key vulnerabilities


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NEW YORK, NY (Jan. 11, 2021) Thousands of different genetic mutations have been implicated in cancer, but a new analysis of almost 10,000 patients found that regardless of the cancer s origin, tumors could be stratified in only 112 subtypes and that, within each subtype, the Master Regulator proteins that control the cancer s transcriptional state were virtually identical, independent of the specific genetic mutations of each patient.
The study, published Jan. 11 in
Cell, confirms that Master Regulators provide the molecular logic that integrates the effect of many different and patient-specific mutations to implement the transcriptional state of a specific tumor subtype, thus greatly expanding the fraction of patients who may respond to the same treatment. ....

New York , United States , Mailman School Of Public Health , Columbia University , Lhospitalet De Llobregat , Comunidad Autonoma De Cataluna , Asuntos Economicosy Transformacion , Prems Subramaniam , Marianoj Alvarez Darwinhealth , Mariano Alverez , Eugenef Douglass , Andrea Califano , Salud Carlos , Marianoj Alvarez , Columbia University Irving Medical Center , Vagelos College Of Physicians , Columbia Precision Oncology Initiative , National Cancer Institute , Catalan Institute Of Oncology , Us National Institutes Of Health , Federicom Giorgi University Of Bologna , School Of Arts , Bellvitge Institute For Biomedical Research , College Of Dental Medicine , Herbert Irving Comprehensive Cancer Center , Evano Paull Columbia University ,