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AstraZeneca : ASCO 2021 Data Support Ambition to Revolutionize Cancer Outcomes by Treating Earlier and Transforming the Patient Experience


AstraZeneca : ASCO 2021 Data Support Ambition to Revolutionize Cancer Outcomes by Treating Earlier and Transforming the Patient Experience
05/19/2021 | 05:06pm EDT
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LYNPARZA is the first targeted medicine to show clinical benefit in the adjuvant setting for patients with germline BRCA-mutated high-risk HER2-negative early breast cancer
CALQUENCE shows sustained four-year clinical benefit in 1st-line chronic lymphocytic leukemia and lower atrial fibrillation rates in previously treated patients vs. ibrutinib
IMFINZI five-year data represent longest-ever survival reported in a Phase III immunotherapy trial in unresectable Stage III lung cancer
AstraZeneca will present new data underscoring its ambition to redefine cancer care at the American Society of Clinical Oncology (ASCO) Annual Meeting, June 4 to 8, 2021. ....

Israel General , United States , Dave Fredrickson , Cristian Massacesi , Daiichi Sankyo Company , American Society Of Clinical Oncology , Daiichi Sankyo Inc , Daiichi Sankyo , Data Monitoring Committee , Stage Development , Company On Twitter Astrazeneca , Merck Co Inc , German Breast Group , American Society , Clinical Oncology , Annual Meeting , Executive Vice President , Oncology Business Unit , Senior Vice President , Late Stage Development , Olympia Phase , Independent Data Monitoring Committee , Non Small Cell , Non Small Cell Metastatic , Molecularly Targeted Agents , Tumor Biology ,

Adjuvant Palbociclib Fails in Early, High-Risk Breast Cancer


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Adding a year of CDK4/6 inhibition to adjuvant endocrine therapy failed to improve invasive disease-free survival (iDFS) in early hormone receptor (HR)-positive breast cancer patients who had residual disease following neoadjuvant chemotherapy, a phase III trial showed.
In the PENELOPE-B study of over 1,200 patients, no difference in the primary endpoint of iDFS was observed between the group receiving palbociclib (Ibrance) and those assigned to placebo, after a median follow-up of 43 months (stratified HR 0.93, 95% CI 0.74-1.17,
P=0.525), reported Sibylle Loibl, MD, PhD, of the German Breast Group.
The addition of 1 year of palbociclib to endocrine therapy in patients with hormone receptor-positive/HER2-negative breast cancer and at high risk of relapse after neoadjuvant chemotherapy does not improve invasive disease-free survival, she said during her presentation at the virtual San Antonio Breast Cancer Symposium (SABCS). No group could be ....

San Antonio , United States , Ruth Oregan , Ian Ingram , University Of Wisconsin , German Breast Group , Sibylle Loibl , German Breast , San Antonio Breast Cancer Symposium , Rutho Regan , Medpage Today , Deputy Managing Editor , Antonio Breast Cancer , சான் அன்டோனியோ , ஒன்றுபட்டது மாநிலங்களில் , ரூத் ஒரேகன் , ஈயந் இஂக்ரம் , பல்கலைக்கழகம் ஆஃப் விஸ்கான்சின் , ஜெர்மன் மார்பக குழு , ஜெர்மன் மார்பக , சான் அன்டோனியோ மார்பக புற்றுநோய் சிம்போசியம் , துணை நிர்வகித்தல் ஆசிரியர் , அன்டோனியோ மார்பக புற்றுநோய் ,