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Role of sleep-related brain activity in clearing toxic proteins and preventing Alzheimer's disease


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IMAGE: The global brain signal in Alzheimer s disease patients is associated with weaker cerebrospinal fluid flow as compared with healthy controls
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Credit: Feng Han and Xiao Liu @ The Pennsylvania State University
Evidence of sleep-dependent low-frequency (PLOS Biology by Xiao Liu and colleagues at The Pennsylvania State University. This neuronal activity was more strongly linked with cerebrospinal fluid flow in healthy controls than higher risk groups and patients, and the findings could serve as a potential imaging marker for clinicians in evaluating patients.
The development of Alzheimer s disease is believed to be driven by the buildup of the toxic proteins amyloid-β and tau in the brain. The brain s glymphatic system plays a crucial role in clearing these toxins and previous work has shown a possible relationship between sleep-dependent global brain activity and the glymphatic system by showing this activity is coupled by cer ....

University Of Southern California , United States , South Korea , Xiao Liu , Eli Lilly , Michael Weiner , Foundation For The National Institutes Of Health , Department Of Defense , Neurorx Research , Meso Scale Diagnostics , National Institute Of Biomedical Imaging , Merck Co Inc , Pfizer Inc , Laboratory For Neuro Imaging , York University , Roche Ltd , Elan Pharmaceuticals Inc , Transition Therapeutics , Alzheimer Disease Neuroimaging Initiative , Eisai Inc , Pennsylvania State University , Boston University , Canadian Institutes Of Health Research , National Institutes Of Health Grant , Johnson Pharmaceutical Research Development , Northern California Institute For Research ,

My Crippling Jaw Pain Turned Out to Be a TMJ Disorder—Here's How I Finally Got It Under Control


My Unbearable Jaw Pain Turned Out to Be a TMJ Disorder Here’s How I Finally Got It Under Control
Prevention
2/26/2021
Alisa Hrustic
My first symptom a swollen, achy neck could’ve been anything. But as spring bloomed into summer, stranger things cropped up. A recurrent pinching sensation in my ears. Sharp pains all around my face. And, far worse than a tension headache, it felt as if a power drill were chiseling away at my temples. I was used to frequent headaches, but this slew of symptoms felt like something else.
It all began in March, just as COVID-19 hit the U.S. After a useless telehealth call with a general physician, I tracked down an ear, nose, and throat specialist (ENT) for another virtual appointment. At the time, I was convinced I had an ear or sinus infection. But she told me it might be a problem with my temporomandibular joint (TMJ). We each have two of them, and they connect the lower jaw to the skull, allowing the mouth t ....

New York , United States , Columbia University , Shuchi Dhadwal , Nojan Bakhtiari , Tammy Chen , Amy Delvecchio , New York Times , Tufts Cranofacial Pain Center , Tufts School Of Dental Medicine , Columbia University College Of Dental Medicine , American Academy Of Orofacial Pain As , New York City , Tufts School , Dental Medicine , American Academy , Orofacial Pain , Pivotal Physical Therapy , புதியது யார்க் , ஒன்றுபட்டது மாநிலங்களில் , கொலம்பியா பல்கலைக்கழகம் , தம்மி சென் , ஆமி டெல்வெச்சியோ , புதியது யார்க் முறை , டஃப்ட்ஸ் பள்ளி ஆஃப் டெஂடல் மருந்து , கொலம்பியா பல்கலைக்கழகம் கல்லூரி ஆஃப் டெஂடல் மருந்து ,

David Kaplan elected to National Academy of Engineering


Credit: Alonso Nichols
David Kaplan, the Stern Family Professor of Engineering, a Distinguished Professor, and chair of the Department of Biomedical Engineering, has been elected to the National Academy of Engineering in recognition of his contributions to silk-based materials for tissue engineering and regenerative medicine. Election to the National Academies is one of the foremost professional recognitions available to engineers, scientists, and medical experts.
On behalf of my past and current students and colleagues here at Tufts, it is an honor to be recognized by the National Academy of Engineering, said Kaplan.
Kaplan s lab is leading efforts in applying tissue engineering to cellular agriculture (i.e. cell grown meat), the development of 3D brain-like environments in the lab to study neurological diseases and treatments, and the regeneration of tissues, organs and limbs. He is also pioneering methods to manufacture biocompatible medical devices from silk. ....

United States , David Kaplan , Tissue Engineering Resource Center , National Institutes Of Health , Tufts School Of Medicine , Department Of Biomedical Engineering , Tufts School Of Dental Medicine , Columbia University , National Academy Of Engineering , Department Of Chemistry , Initiative For Neural Science , Gordon Research Conference , National Academies , Department Of Chemical , Stern Family Professor , Distinguished Professor , Biomedical Engineering , National Academy , Neural Science , National Institutes , Engineering Resource Center , Tufts School , Dental Medicine , Nature Biotechnology , American Institute , Biological Engineering ,