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Why some cancer drugs may be ineffective

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Sun Apr 18 2021
A possible explanation for why many cancer drugs that kill tumor cells in mouse models won’t work in human trials has been found.

A possible explanation for why many cancer drugs that kill tumor cells in mouse models won’t work in human trials has been found by researchers with The University of Texas Health Science Center at Houston (UTHealth) School of Biomedical Informatics and McGovern Medical School.
The research was published today in Nature Communications.
In the study, investigators reported the extensive presence of mouse viruses in patient-derived xenografts (PDX). PDX models are developed by implanting human tumor tissues in immune-deficient mice, and are commonly used to help test and develop cancer drugs. ....

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know why recent research says cancer tumor drugs are ineffective in human body - ट्यूमर दवाएं शोध में बेअसर,ये है वजह

know why recent research says cancer tumor drugs are ineffective in human body - ट्यूमर दवाएं शोध में बेअसर,ये है वजह
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Research finds possible explanation for why many cancer drugs don't work in human trials

Research finds possible explanation for why many cancer drugs don t work in human trials
A possible explanation for why many cancer drugs that kill tumor cells in mouse models won t work in human trials has been found by researchers with The University of Texas Health Science Center at Houston (UTHealth) School of Biomedical Informatics and McGovern Medical School.
The research was published today in
Nature Communications.
In the study, investigators reported the extensive presence of mouse viruses in patient-derived xenografts (PDX). PDX models are developed by implanting human tumor tissues in immune-deficient mice, and are commonly used to help test and develop cancer drugs. ....

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Study on cancer drugs

Study on cancer drugs
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Study finds why some cancer drugs may be ineffective

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A possible explanation for why many cancer drugs that kill tumor cells in mouse models won t work in human trials has been found by researchers with The University of Texas Health Science Center at Houston (UTHealth) School of Biomedical Informatics and McGovern Medical School.
The research was published today in
Nature Communications.
In the study, investigators reported the extensive presence of mouse viruses in patient-derived xenografts (PDX). PDX models are developed by implanting human tumor tissues in immune-deficient mice, and are commonly used to help test and develop cancer drugs.
What we found is that when you put a human tumor in a mouse, that tumor is not the same as the tumor that was in the cancer patient, said W. Jim Zheng, PhD, professor at the School of Biomedical Informatics and senior author on the study. The majority of tumors we tested were compromised by mouse viruses. ....

United States , Wuhua Xu , W Jim Zheng , Uthealth Neurosciences , Jay Jiguang Zhu , Ningyan Zhang , Jiaqian Wu , Ming Fu , Nature Communications , School Of Biomedical Informatics , Informatics Core For Cancer Research , Texas Therapeutic Institute , National Institutes Of Health , Roberta Welch Distinguished University , Institute Of Molecular Medicine , Welch Foundation , Mcgovern Medical School , Chemistry At Mcgovern Medical School , School Of Biomedical Informatic , Texas Therapeutics Institute , Research Institute Of Texas , Texas Health Science Center , Biomedical Informatics , Mcgovern Medical , Molecular Medicine , Data Science ,