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Why some cancer drugs may be ineffective


By
Sun Apr 18 2021
A possible explanation for why many cancer drugs that kill tumor cells in mouse models won’t work in human trials has been found.
 
A possible explanation for why many cancer drugs that kill tumor cells in mouse models won’t work in human trials has been found by researchers with The University of Texas Health Science Center at Houston (UTHealth) School of Biomedical Informatics and McGovern Medical School.
The research was published today in Nature Communications.
In the study, investigators reported the extensive presence of mouse viruses in patient-derived xenografts (PDX). PDX models are developed by implanting human tumor tissues in immune-deficient mice, and are commonly used to help test and develop cancer drugs. ....

United States , Wuhua Xu , W Jim Zheng , Uthealth Neurosciences , Jay Jiguang Zhu , Ningyan Zhang , Jiaqian Wu , Ming Fu , Nature Communications , School Of Biomedical Informatics , Informatics Core For Cancer Research , Texas Therapeutic Institute , National Institutes Of Health , Roberta Welch Distinguished University , Institute Of Molecular Medicine , Welch Foundation , Mcgovern Medical School , Chemistry At Mcgovern Medical School , School Of Biomedical Informatic , Texas Therapeutics Institute , Research Institute Of Texas , Texas Health Science Center , Biomedical Informatics , Mcgovern Medical , Molecular Medicine , Data Science ,

Research finds possible explanation for why many cancer drugs don't work in human trials


Research finds possible explanation for why many cancer drugs don t work in human trials
A possible explanation for why many cancer drugs that kill tumor cells in mouse models won t work in human trials has been found by researchers with The University of Texas Health Science Center at Houston (UTHealth) School of Biomedical Informatics and McGovern Medical School.
The research was published today in
Nature Communications.
In the study, investigators reported the extensive presence of mouse viruses in patient-derived xenografts (PDX). PDX models are developed by implanting human tumor tissues in immune-deficient mice, and are commonly used to help test and develop cancer drugs. ....

United States , W Jim Zheng , Emily Henderson , Nature Communications , School Of Biomedical Informatics , Informatics Core For Cancer Research , Roberta Welch Distinguished University , Institute Of Molecular Medicine , Mcgovern Medical School , Chemistry At Mcgovern Medical School , Texas Therapeutics Institute , School Of Biomedical Informatic , Texas Health Science Center , Biomedical Informatics , Mcgovern Medical , Molecular Medicine , Data Science , Informatics Core , Cancer Research , Biomedical Informatic , Distinguished University Chair , Medical School , ஒன்றுபட்டது மாநிலங்களில் , டப்ல்யூ ஜிம் ஜெங் , எமிலி ஹென்டர்சன் , இயற்கை தகவல்தொடர்புகள் ,