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Study on cancer drugs

Study on cancer drugs
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Study finds why some cancer drugs may be ineffective

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A possible explanation for why many cancer drugs that kill tumor cells in mouse models won t work in human trials has been found by researchers with The University of Texas Health Science Center at Houston (UTHealth) School of Biomedical Informatics and McGovern Medical School.
The research was published today in
Nature Communications.
In the study, investigators reported the extensive presence of mouse viruses in patient-derived xenografts (PDX). PDX models are developed by implanting human tumor tissues in immune-deficient mice, and are commonly used to help test and develop cancer drugs.
What we found is that when you put a human tumor in a mouse, that tumor is not the same as the tumor that was in the cancer patient, said W. Jim Zheng, PhD, professor at the School of Biomedical Informatics and senior author on the study. The majority of tumors we tested were compromised by mouse viruses. ....

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Madlock-Brown participating in national COVID data research collaborative

Credit: UTHSC
Memphis, Tenn. (January 8, 2021) - One of UTHSC s data scientists is applying her extensive expertise in informatics to a national effort to leverage big data in the fight against COVID-19.
Charisse Madlock-Brown, PhD, MLS, a faculty member in Health Informatics and Information Management at UTHSC, is a co-lead for one of the clinical domain teams of the National COVID Cohort Collaborative (N3C). The N3C is a partnership among the National Center for Data to Health- and National Center for Advancing Translational Sciences-supported Clinical and Translational Science Awards (CTSA) Program hubs. It includes clinicians, informaticians, and biomedical researchers from more than 60 institutions working to turn data from hundreds of thousands of medical records from coronavirus patients into treatments and predictive analytical tools that can help address the evolving pandemic. ....

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