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Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes

Most analyses of the antibody responses induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have focused on antibodies cloned from memory B cells. This approach has led researchers to conclude that neutralizing antibodies (nAbs) primarily target the receptor-binding domain (RBD) of the virus s spike protein. Voss et al. took a different approach, using proteomic deconvolution of the serum immunoglobulin G antibody repertoire from four COVID-19 convalescent patients. They found that the nAb response was largely directed against epitopes such as the N-terminal domain (NTD), which lie outside the RBD. Several of these nAbs were shared among donors and targeted an NTD epitope that is frequently mutated by variants of concern.

Science , abg5268, this issue p. [1108][1]

The molecular composition and binding epitopes of the immunoglobulin G (IgG) antibodies that circulate in blood plasma after severe acute respiratory syndrome coronavirus 2 (SARS-Co ....

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Timing the SARS-CoV-2 index case in Hubei province

Timing the SARS-CoV-2 index case in Hubei province
sciencemag.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencemag.org Daily Mail and Mail on Sunday newspapers.

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HealthLX & Verinovum Partner to Integrate Data Quality Assessment and Improvement with FHIR Solutions for Interoperability Compliance

HealthLX & Verinovum Partner to Integrate Data Quality Assessment and Improvement with FHIR Solutions for Interoperability Compliance
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GRAFTON, Wis. (PRWEB)
March 16, 2021
HealthLX announced today that it has formalized a technology partnership with Verinovum to help payers integrate data quality assessment and improvement into their FHIR-based solutions for compliance with the CMS Interoperability and Patient Access final rule. Health plans in the United States are required to enable member access to their records by July 1, 2021 or risk enforcement actions.
“Payers are turning to us for a compliance strategy. We’re helping them meet their needs and looking beyond to find ways to make interoperability a strategic advantage for them,” said Will Tesch, CEO of HealthLX. ”Data quality assurance is an essential driver for this goal, and we’re very pleased to partner with Veri ....

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Data Curation Consultant

Information Management Consultancy in USA about Agriculture, Disaster Management and Food and Nutrition, requiring 0-2 years of experience, from Chemonics; closing on 24 Jan 2021 ....

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Tech Trends in 2021 To Grow Your Business - Market Business News

Tech Trends in 2021 To Grow Your Business - Market Business News
marketbusinessnews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from marketbusinessnews.com Daily Mail and Mail on Sunday newspapers.

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