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Most Americans generally oppose animal testing — will the U.S. finally ban it?

The life of a mouse or a rat is an unenviable one. Chances are that if you re in the urban wild, you must contend with deadly traps, poisons and broom-wielding humans. If you re a country-dweller, you might have it a bit easier, but then again you may be blown to smithereens by a shotgun or carried off in the sharp talons of a barn owl. Or be poisoned anyway. The only good mouse is a dead mouse, Australia s deputy prime minister Michael McCormack said recently, as the nation ramped up its war on mice with a plan to poison millions of them in New South Wales. ....

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Worldwide network develops SARS-CoV-2 protocols for research laboratories

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IMAGE: Scientists Martin Hengesbach (left) und Andreas Schlundt at the nuclear magnetic resonance (NMR) spectrometre at Goethe-University Frankfurt, Germany.
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Credit: Uwe Dettmar for Goethe-University Frankfurt, Germany
FRANKFURT. When the SARS-CoV-2 virus mutates, this initially only means that there is a change in its genetic blueprint. The mutation may lead, for example, to an amino acid being exchanged at a particular site in a viral protein. In order to quickly assess the effect of this change, a three-dimensional image of the viral protein is extremely helpful. This is because it shows whether the switch in amino acid has consequences for the function of the protein - or for the interaction with a potential drug or antibody. ....

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Study: Vitamin D won't limit risk, severity of COVID-19

May 7, 2021
New Cornell-led research finds “little to no evidence” of a link between a person’s normal blood levels of vitamin D and risk of getting COVID-19, or the severity of an infection, in the most comprehensive study of its kind to date.
Multiple studies had suggested an association between vitamin D and COVID-19 risk, raising hopes that vitamin D supplements might help to prevent or minimize infections – speculation that has received widespread media attention and boosted consumer interest.
The new study, however, which analyzed a publicly available genomic data bank and 38 different COVID-19 studies worldwide – a total sample including nearly 1.4 million people – does not support those claims. ....

United Kingdom , Nathan Gaddis , Bonnie Patchen , Aland Mathios , Dana Hancock , Andrewg Clark , Patriciaa Cassano , Division Of Nutritional Sciences , National Institutes Of Health , College Of Agriculture , Translational Research Center , Department Of Molecular Biology , Department Of Computational Biology , Cornell Anns Bowers College Of Computing , College Of Human Ecology , Department Molecular Biology , College Of Arts , Life Sciences , Cassano Research Group , New Cornell Led , Cassano Research , Mendelian Randomization Study , Human Ecology , Nutritional Sciences , Computational Biology , National Institutes ,

Agrawal, Hanson elected to National Academy of Sciences

May 3, 2021
Anurag Agrawal, the James A. Perkins Professor of Environmental Studies in the College of Agriculture and Life Sciences, and Maureen Hanson, the Liberty Hyde Bailey Professor in the Department of Molecular Biology and Genetics (CALS, Arts and Sciences), have been elected to the National Academy of Sciences, the academy announced April 26.
The election of 120 members – 59 of whom are women, the most elected in a single year – brings the total number of active members to 2,461.
“The historic number of women elected this year reflects the critical contributions that they are making in many fields of science, as well as a concerted effort by our Academy to recognize those contributions and the essential value of increasing diversity in our ranks,” Marcia McNutt, president of the National Academy of Sciences (NAS), said in a statement. “I am pleased to welcome all of our new members, and I look forward to engaging with them in the work of the Nationa ....

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How diet controls RNA maturation

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How diet controls RNA maturation
Two UNIGE teams have discovered a new mechanism for regulating RNA maturation that depends on diet.
The nematode C. elegans at two developmental stages: a larva and a developing embryo. © Joanna Wenda
Particularly sensitive to chemical modifications, messenger RNAs (mRNAs) are molecules responsible for transmitting the information encoded in our genome, allowing for the synthesis of proteins, which are necessary for the functioning of our cells. Two teams from the University of Geneva (UNIGE), Switzerland, in collaboration with the Norwegian University of Science and Technology (NTNU), have focused on a specific type of chemical modification – called methylation – of mRNA molecules in the small worm Caenorhabditis elegans. They found that methylation on a particular sequence of an mRNA leads to its degradation and that this control mechanism depends on the worm’s diet. These findings are to be read in the journal Ce ....

Mateusz Mendel , Ramesh Pillai , Joanna Wenda , Ueli Schibler , Florian Steiner , Department Of Molecular Biology , University Of Geneva , Norwegian University Of Science , Norwegian University , Molecular Biology , Kamila Delaney , ரமேஷ் பிள்ளை , புளோரியன் ஸ்டீனர் , துறை ஆஃப் மூலக்கூறு உயிரியல் , பல்கலைக்கழகம் ஆஃப் ஜிநீவ , நோர்வே பல்கலைக்கழகம் ஆஃப் அறிவியல் , நோர்வே பல்கலைக்கழகம் , மூலக்கூறு உயிரியல் ,