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Researchers use anesthetics to study reemerging consciousness, cognitive function after anesthesia

Millions of surgical procedures performed each year would not be possible without the aid of general anesthesia, the miraculous medical ability to turn off consciousness in a reversible and controllable way. ....

United States , Michael Avidan , Max Kelz , George Mashour , Emily Henderson , University Of Michigan , National Institutes Of Health Bethesda , Washington University , Jamess Mcdonnell Foundation , University Of Michigan Medical School , University Of Pennsylvania , University Of Pennsylvania Medical School , Michigan Medical School , Michigan Medicine , Pennsylvania Medical School , Washington University School , Odonnell Foundation , National Institutes , Ognitive Function , Medical School , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் மிச்சிகன் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் பெதஸ்தா , வாஷிங்டன் பல்கலைக்கழகம் , ஜமெஸ்ச் மக்டொநெல் அடித்தளம் ,

Escape from oblivion: How the brain reboots after deep anesthesia

Credit: Jacob Dwyer, Michigan Medicine
Millions of surgical procedures performed each year would not be possible without the aid of general anesthesia, the miraculous medical ability to turn off consciousness in a reversible and controllable way.
Researchers are using this powerful tool to better understand how the brain reconstitutes consciousness and cognition after disruptions caused by sleep, medical procedures requiring anesthesia, and neurological dysfunctions such as coma.
In a new study published in the journal
eLife, a team led by anesthesiologists George Mashour, M.D., Ph.D. of University of Michigan Medical School, Michigan Medicine, Max Kelz, M.D., Ph.D. of the University of Pennsylvania Medical School, and Michael Avidan, MBBCh of the Washington University School of Medicine used the anesthetics propofol and isoflurane in humans to study the patterns of reemerging consciousness and cognitive function after anesthesia. ....

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[Full text] Protein Nanoparticle-Related Osmotic Pressure Modifies Nonselective Pe

Figure 1 Construction of occludin/ZO1 probes and analysis of their efficacy and motility. (
A) In cpstFRET (cpVenus-7aa-cpCerulean), cpCerulean (cyan) is the donor and cpVenus (yellow) is the acceptor. The probes have high Förster resonance energy transfer (FRET) efficiency when donor and acceptor are parallel without external force (f: external force). The external force reduces the FRET efficiency by changing the angle of cpstFRET. (
B) Schematic representation of the occludin/ZO1 probe constructs. The cpstFRET module was inserted between amino acids 357 and 358 in the occludin probe and between amino acids 1011 and 1012 in the ZO1 probe. (
C) FRET acceptor photobleaching (FRET-AB) was used to test the efficacy of the occludin (left) and ZO1 (right) probes in HBMEC cells. FRET-AB efficiency was 17.435% for the occludin probe and 17.02% for the ZO1 probe. ( ....

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2 Montgomery County Hospitals Ranked Among 2021's Best

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A new ranking by Healthgrades evaluates the top 50, 100, and 250 hospitals in America. These two Montgomery County hospitals made the list. (Shutterstock)
SILVER SPRING, MD As the coronavirus places renewed importance on our access to safe, quality health care, a new ranking by Healthgrades has recognized two hospitals in Montgomery County for superior performance in the years leading up to the pandemic.
Healthgrades, an online health care information company, recently released its 2021 list of America s Best Hospitals. The annual ranking recognizes the top 1, 2, and 5 percent of hospitals in the nation.
To compile the ranking, researchers looked at Centers for Medicare and Medicaid data from fiscal years 2017-19 for more than 4,500 hospitals nationwide. Researchers then analyzed how each performed across 32 conditions and procedures including heart attack, heart failure, pneumonia, respiratory failure, sepsis, and stroke. ....

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