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Pigs' brain size and digestive system are excellent analogs for human newborns


Pigs’ brain size and digestive system are excellent analogs for human newborns
Before humans can benefit from new drug therapies and nutritional additives, scientists test their safety and efficacy in animals, typically mice and rats. But, as much as they ve done for biomedical research, rodents aren t always the best research model for studies on neonatal brain development and nutrition. That s where pigs can play an important role.
University of Illinois researchers say the domestic pig is ideal for these studies because their brain size, rate of development, and digestive system are excellent analogs for human newborns.
They know a lot about pig brains, having built the first - and recently, the second - complete, MRI-based atlases of the organ. They ve used the first to study the effects of numerous nutritional interventions in pigs. But some critics say they can t be sure those outcomes reflect reality. After all, these research subjects are raised in carefully ....

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In pig brain development, nature beats nurture


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IMAGE: Using a newly developed pig brain atlas, University of Illinois researchers show no major differences in pig brain development between pigs in artificial rearing environments vs. sow rearing. The discovery.
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Credit: Lauren D. Quinn, University of Illinois
URBANA, Ill. - Before humans can benefit from new drug therapies and nutritional additives, scientists test their safety and efficacy in animals, typically mice and rats. But, as much as they ve done for biomedical research, rodents aren t always the best research model for studies on neonatal brain development and nutrition. That s where pigs can play an important role.
University of Illinois researchers say the domestic pig is ideal for these studies because their brain size, rate of development, and digestive system are excellent analogues for human newborns. ....

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Pig brain atlas gives a more precise view of human brain


Pig brain atlas gives a more precise view of human brain
When scientists need to understand the effects of new infant formula ingredients on brain development, it s rarely possible for them to carry out initial safety studies with human subjects. After all, few parents are willing to hand over their newborns to test unproven ingredients.
Enter the domestic pig. Its brain and gut development are strikingly similar to human infants - much more so than traditional lab animals, rats and mice. And, like infants, young pigs can be scanned using clinically available equipment, including non-invasive magnetic resonance imaging, or MRI. That means researchers can test nutritional interventions in pigs, look at their effects on the developing brain via MRI, and make educated predictions about how those same nutrients will affect human infants. ....

United States , University Of Illinois , Siemens Prisma , Brad Sutton , Ryan Dilger , Emily Henderson , Biomedical Imaging Center At Illinoi Beckman Institute , Department Of Animal Sciences , Beckman Biomedical Imaging Center , Neuroscience Program , Neuroscience Program At Illinois , Biomedical Imaging Center , Illinoi Beckman Institute , Animal Sciences , Joanne Fil , Study Lead Author , Doctoral Student , ஒன்றுபட்டது மாநிலங்களில் , பல்கலைக்கழகம் ஆஃப் இல்லினாய்ஸ் , ஸீமெந்ஸ் பிரீஸ்ம , பிராட் சுட்டன் , ரியான் தில்கேர் , எமிலி ஹென்டர்சன் , துறை ஆஃப் விலங்கு அறிவியல் , பெக்மேன் உயிர் மருத்துவ இமேஜிங் மையம் , நரம்பியல் ப்ரோக்ர்யாம் ,