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THERANEXUS: THERANEXUS EXTENDS THE CAPABILITIES OF NEUROLEAD, ITS ACTIVE AGENT SCREENING PLATFORM, TO AUTOPHAGY AND NEUROLOGICAL LYSOSOMAL STORAGE DISORDERS


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Lyon, 9 March 2021 - Theranexus, a biopharmaceutical company innovating in the treatment of neurological diseases and pioneer in the development of drug candidates modulating the interaction between neurons and glial cells, today announced that it has extended the capabilities of Neurolead, its drug candidate discovery platform, to include autophagy and neurological manifestations of lysosomal storage disorders.
Neurolead, which combines the latest innovations in neuroscience and artificial intelligence, is a platform for the generation of new drug candidates based on a unique concept, the therapeutic targeting of interactions between glial and neuronal cells. By applying Neurolead to autophagy and neurological forms of lysosomal storage disorders, Theranexus is taking its research in the direction of exploring a therapeutic avenue of major interest with clear medical and economic potential. ....

France General , Haute Normandie , Mathieu Charv , Lysosomal Storage Disorders Association , Atomic Energy Commission , Theranexus Chief Scientific , French Alternative Energies , Euronext Growth , பிரான்ஸ் ஜநரல் , ஹாட் நார்மண்டி , அணு ஆற்றல் தரகு , பிரஞ்சு மாற்று ஆற்றல்கள் ,

Scientists receive the Brain Prize for groundbreaking contributions to novel migraine therapies


Scientists receive the Brain Prize for groundbreaking contributions to novel migraine therapies
What:
The Brain Prize has been awarded to Michael A. Moskowitz, M.D., a professor of neurology at Harvard Medical School at the Massachusetts General Hospital, Charlestown, who also is supported by an NIH grant.
The Brain Prize is the world s most prestigious award for brain research and is awarded by the Lundbeck Foundation, Denmark. Dr. Moskowitz will receive the prize along with three other scientists for their pathbreaking contributions that led to novel migraine therapies.
The Lundbeck Foundation said, Moskowitz showed in experimental models that a migraine attack is triggered when trigeminal nerve fibers release neuropeptides that lead to dilated (opened up) blood vessels of the meninges, inflammation, and pain.. He was the first to propose that blocking the action of released neuropeptides could be a new approach to treating migraine. ....

United States , Michaela Moskowitz , Emily Henderson , Lundbeck Foundation , Harvard Medical School , National Institute Of Neurological Disorders , Brain Prize , Massachusetts General Hospital , Neurological Disorders , Medical Research , Medical School , Nervous System , ஒன்றுபட்டது மாநிலங்களில் , மைக்கேலா மோஸ்கோவித்ஜ் , எமிலி ஹென்டர்சன் , ஹார்வர்ட் மருத்துவ பள்ளி , தேசிய நிறுவனம் ஆஃப் நரம்பியல் கோளாறுகள் , மூளை ப்ரைஸ் , மாசசூசெட்ஸ் ஜநரல் மருத்துவமனை , நரம்பியல் கோளாறுகள் , ஒற்றைத் தலைவலி , மருத்துவ ஆராய்ச்சி , மருத்துவ பள்ளி , பதட்டமாக அமைப்பு ,

Study shows how mutant huntingtin protein triggers brain cell death


Study shows how mutant huntingtin protein triggers brain cell death
In 1993, scientists discovered that a single mutated gene, HTT, caused Huntington s disease, raising high hopes for a quick cure. Yet today, there s still no approved treatment.
One difficulty has been a limited understanding of how the mutant huntingtin protein sets off brain cell death, says neuroscientist Srinivasa Subramaniam, Ph.D., of Scripps Research, Florida.
In a new study published in
Nature Communications on Friday, Subramaniam s group has shown that the mutated huntingtin protein slows brain cells protein-building machines, called ribosomes.
The ribosome has to keep moving along to build the proteins, but in Huntington s disease, the ribosome is slowed. The difference maybe two, three, four-fold slower. That makes all the difference. ....

United States , Srinivasa Subramaniam , Emily Henderson , Scripps Research , Scripps Research Institute , Nature Communications On , Nature Communications , Huntington 39s Disease , Brain Cell , Cell Death , Protein Synthesis , ஒன்றுபட்டது மாநிலங்களில் , ஸ்ரீநிவாச சுப்ரமணியம் , எமிலி ஹென்டர்சன் , ஸ்கிரிப்ட்கள் ஆராய்ச்சி , ஸ்கிரிப்ட்கள் ஆராய்ச்சி நிறுவனம் , இயற்கை தகவல்தொடர்புகள் ஆன் , இயற்கை தகவல்தொடர்புகள் , மூளை செல் , செல் இறப்பு , ப்ரோடீந் தொகுப்பு ,