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Research offers insights on how night shift work increases cancer risk


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IMAGE: A night shift schedule is associated with increased DNA damage and misalignment of the DNA repair mechanism, providing a possible explanation for the elevated risk of cancer in night shift.
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Credit: Bala Koritala
SPOKANE, Wash. - New clues as to why night shift workers are at increased risk of developing certain types of cancer are presented in a new study conducted at Washington State University Health Sciences Spokane.
Journal of Pineal Research, the study involved a controlled laboratory experiment that used healthy volunteers who were on simulated night shift or day shift schedules. Findings from the study suggest that night shifts disrupt natural 24-hour rhythms in the activity of certain cancer-related genes, making night shift workers more vulnerable to damage to their DNA while at the same time causing the body s DNA repair mechanisms to be mistimed to deal with that damage. ....

Hugh Mitchell , Van Dongen , Jason Mcdermott , Kenneth Porter , Justin Teeguarden , Hans Van Dongen , Mugimane Manjanatha , Rajendra Gajula , Tarana Arman , Osama Arshad , Bala Koritala , Shobhan Gaddameedhi , Performance Research Center , National Institutes Of Health , Pacific Northwest National Laboratory , Research Programs , Elsons Floyd College Of Medicine , Pacific Northwest National Laboratory Biological Sciences Division , Carolina State University Biological Sciences Department , Journal Of Pineal Research , Washington State University Health Sciences Spokane , Human Health , College Of Pharmacy , Health Sciences Spokane , Washington State University Health Sciences , Pineal Research ,

Convincing evidence that type 2 diabetes is associated with increased risk of Parkinson's

Research from Queen Mary University of London has concluded that there is convincing evidence that type 2 diabetes is associated with an increased risk of Parkinson s disease. The same study found that there was also evidence that type 2 diabetes may contribute to faster disease progression in patients who already have Parkinson s. ....

National Institute On , Movement Disorders Journal , Canada First Research Excellence Fund , Canadian Consortium On Neurodegeneration , Queen Mary University Of London , Michaelj Fox Foundation , Barts Charity , Intramural Research Program , Queen Mary University , Preventive Neurology Unit , Canadian Consortium , Parkinson Canada , National Institute , Medicine Health , Parkinsons Disease , தேசிய நிறுவனம் ஆன் , இயக்கம் கோளாறுகள் இதழ் , கனடா முதல் ஆராய்ச்சி சிறப்பானது நிதி , ராணி மேரி பல்கலைக்கழகம் ஆஃப் லண்டன் , மரப்பட்டைகள் தொண்டு , அகச்சிதைவு ஆராய்ச்சி ப்ரோக்ர்யாம் , ராணி மேரி பல்கலைக்கழகம் , ப்ரெவெஂடிவ் நரம்பியல் அலகு , கனடியன் கூட்டமைப்பு , பார்கின்சன் கனடா , தேசிய நிறுவனம் ,

Cognitive fatigue changes functional connectivity in brain's fatigue network


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IMAGE: Dr. Wylie, director of the Rocco Ortenzio Neuroimaging Center at Kessler Foundation, specializes in the implementation of neuroimaging techniques in rehabilitation research.
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Credit: Kessler Foundation
East Hanover, NJ. March 8, 2021. Kessler Foundation researchers have demonstrated changes in the functional connectivity within the fatigue network in response to cognitive fatigue. This finding, the first of its kind, was reported in
Scientific Reports on December 14, 2020 in the open access article, Using functional connectivity changes associated with cognitive fatigue to delineate a fatigue network (doi: 10.1038//s41598-020-78768-3).
The authors are Glenn Wylie, DPhil, Brian Yao, PhD, Helen M. Genova, PhD, Michele H. Chen, PhD, and John DeLuca, PhD, of Kessler Foundation. All have faculty appointments at Rutgers New Jersey Medical School. Dr. Wylie is also a research scientist at The Department of Veterans Affairs ....

New Jersey , United States , East Hanover , Helenm Genova , Glenn Wylie , Micheleh Chen , John Deluca , Brian Yao , Illness Study Center , Rocco Ortenzio Neuroimaging Center At Kessler Foundation , Kessler Foundation , Jersey Commission For Brain Injury Research , Ortenzio Center , Department Of Veteran Affairs , Rutgers New Jersey Medical School , Department Of Veteran Affairs Injury , Scientific Reports , Rutgers New Jersey Medical , Veteran Affairs War Related Injury , New Jersey Healthcare , Gulf War Illness , Rocco Ortenzio Neuroimaging Center , New Jersey Commission , Brain Injury Research , Veteran Affairs , Join Our Research Studies ,

Why odors trigger powerful memories

Odors evoke powerful memories, an experience enshrined in literature by Marcel Proust and his beloved madeleine. A new paper is the first to identify a neural basis for how the brain enables odors to so powerfully elicit those memories. The paper shows unique connectivity between the hippocampus the seat of memory in the brain and olfactory areas in humans. It s like a superhighway from smell to the hippocampus. ....

United States , Guangyu Zhou , Christina Zelano , Marcel Proust , Swedish Research Council , Alice Wallenberg Foundation , Northwestern University Feinberg School Of Medicine , National Institute On Deafness , Northwestern Medicine , Northwestern University Feinberg School , National Institute , Swedish Research , Medicine Health , Infectious Emerging Diseases , Olfactory Taste , Memory Cognitive Processes , ஒன்றுபட்டது மாநிலங்களில் , கிறிஸ்டினா ஜெழானோ , மார்செல் ப்ரௌஸ்ட் , ஸ்விட்ச் ஆராய்ச்சி சபை , ஆலிஸ் வாலன்பெர்க் அடித்தளம் , வடமேற்கு பல்கலைக்கழகம் ஃபைன்பெர்க் பள்ளி ஆஃப் மருந்து , தேசிய நிறுவனம் ஆன் காது கேளாமை , வடமேற்கு மருந்து , வடமேற்கு பல்கலைக்கழகம் ஃபைன்பெர்க் பள்ளி , தேசிய நிறுவனம் ,