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Researchers reveal process behind harmful glial cell change in motor neurone disease

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Scientists at the Francis Crick Institute and UCL have identified the trigger of a key cellular change in amyotrophic lateral sclerosis (ALS), a type of motor neurone disease. The findings could help develop new treatments for many neurological diseases with the same change, including Parkinson s and Alzheimer s.
When the nervous system is injured, diseased or infected, star-shaped cells, called astrocytes, undergo reactive changes in their behaviour. Whilst some of these reactive astrocytes become protective, others become harmful and damage surrounding motor neurons.
Reactive astrocytes are observed in various neurodegenerative diseases including ALS, but there is a lack of understanding about what causes astrocytes to undergo this change. ....

United Kingdom , City Of , Oliver Ziff , Rickie Patani , University College London , King College London , Queen Square Institute Of Neurology , Nucleic Acids Research , National Hospital For Neurology , Imperial College London , Cancer Research United Kingdom , Research Council , Francis Crick Institute , Square Institute , National Hospital , Medical Research Council , Cell Biology , Medicine Health , ஒன்றுபட்டது கிஂக்டம் , நகரம் ஆஃப் , ஆலிவர் ஸிஃப் , ரிக்கி படானி , பல்கலைக்கழகம் கல்லூரி லண்டன் , கிங் கல்லூரி லண்டன் , ராணி சதுரம் நிறுவனம் ஆஃப் நரம்பியல் , தேசிய மருத்துவமனை க்கு நரம்பியல் ,

Researchers Identify Brain Ion Channel as New Approach to Treating Depression

Mount Sinai
Researchers from the Icahn School of Medicine at Mount Sinai have identified a drug that works against depression by a completely different mechanism than existing treatments.
Their study showed that ezogabine (also known as retigabine), a drug that opens KCNQ2/3 type of potassium channels in the brain, is associated with significant improvements in depressive symptoms and anhedonia in patients with depression. Anhedonia is the reduced ability to experience pleasure or lack of reactivity to pleasurable stimuli; it is a core symptom of depression and associated with worse outcomes, poor response to antidepressant medication, and increased risk of suicide. ....

United States , South Korea , James Murrough , National Institute Of Mental Health , Icahn School Of Medicine At Mount Sinai , Anxiety Center , Professor Of Pharmacological Sciences , Drug Administration , Friedman Brain Institute , Ehrenkranz Laboratory For Human Resilience , Icahn School , Mount Sinai , American Journal , Associate Professor , Ming Hu Han , Pharmacological Sciences , Montgomery Asberg Depression Rating Scale , Quick Inventory , Depressive Symptomatology Self Report , Snaith Hamilton Pleasure Scale , Temporal Experience , Pleasure Scale , National Institute , Ehrenkranz Laboratory , Human Resilience , Clinical Trial ,

Researchers identify the trigger of key cellular change in amyotrophic lateral sclerosis

Researchers identify the trigger of key cellular change in amyotrophic lateral sclerosis
Scientists at the Francis Crick Institute and UCL have identified the trigger of a key cellular change in amyotrophic lateral sclerosis (ALS), a type of motor neurons disease. The findings could help develop new treatments for many neurological diseases with the same change, including Parkinson s and Alzheimer s.
When the nervous system is injured, diseased or infected, star-shaped cells, called astrocytes, undergo reactive changes in their behavior. Whilst some of these reactive astrocytes become protective, others become harmful and damage surrounding motor neurons.
Reactive astrocytes are observed in various neurodegenerative diseases including ALS, but there is a lack of understanding about what causes astrocytes to undergo this change. ....

Oliver Ziff , Rickie Patani , Emily Henderson , National Hospital For Neurology , Queen Square Institute Of Neurology , Group Leader , Nucleic Acids Research , Francis Crick Institute , Senior Study Author , Queen Square Institute , Consultant Neurologist , National Hospital , Square Institute , Motor Neurone Disease , Amyotrophic Lateral Sclerosis , Genetic Information , Motor Neurons , Nervous System , Neurodegenerative Diseases , Stem Cells , ஆலிவர் ஸிஃப் , ரிக்கி படானி , எமிலி ஹென்டர்சன் , தேசிய மருத்துவமனை க்கு நரம்பியல் , ராணி சதுரம் நிறுவனம் ஆஃப் நரம்பியல் , குழு தலைவர் ,

When peaking at your brain may help with mental illness

In recent years, researchers have begun using functional magnetic resonance imaging (fMRI) not just to better understand the neural bases of psychiatric illness, but also for experimental treatment of depression, ADHD, anxiety, PTSD, substance use disorder, and schizophrenia with real-time fMRI neurofeedback. But how well does it work? ....

New York , United States , University Of Rochester , David Dodell Feder , Emily Dudek , Department Of Psychology , University Medical Center , Brain Injury Research Center , Department Of Neuroscience , Medical Center , Mount Sinai , Medicine Health , Social Behavioral Science , Personality Attitude , Mental Health , Decision Making Problem Solving , Depression Anger , Perception Awareness , Stress Anxiety , புதியது யார்க் , ஒன்றுபட்டது மாநிலங்களில் , பல்கலைக்கழகம் ஆஃப் ரோசெஸ்டர் , எமிலி ட்யூடெக் , துறை ஆஃப் உளவியல் , பல்கலைக்கழகம் மருத்துவ மையம் , மூளை காயம் ஆராய்ச்சி மையம் ,

Study finds high rate of cardiovascular risk factors among U.S. Hispanic/Latino population

Study finds high rate of cardiovascular risk factors among U.S. Hispanic/Latino population
The rate of cardiovascular risk factors among Hispanic/Latino people living in the U.S. is very high, and while they are often aware of their health conditions, less than half of the Hispanic/Latino adults with history of stroke or transient ischemic attack (TIA) had healthy blood pressure and cholesterol, and about half had healthy blood sugar levels.
According to new research published today in
Stroke, a journal of the American Stroke Association, a division of the American Heart Association.
According to the American Heart Association, from 2015 to 2018, 52.3% of Hispanic men and 42.7% of Hispanic women aged 20 years and older had cardiovascular disease (CVD). ....

United States , New York , University Of Illinois At Chicago , Puerto Rico , San Diego , Puerto Rican , Fernandod Testai , Emily Henderson , American Heart Association , American Stroke Association , Study Co , Driver Of Health Disparities , Hispanic Community Health Study Of Latinos , American Heart , Study Co Author , Associate Professor , Hispanic Community Health , South American , New York City , Structural Racism , Fundamental Driver , Health Disparities , Cardiovascular Quality , Blood Pressure , Blood Sugar , Cardiovascular Disease ,