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Immune cells in blood influence the brain during early development of Parkinson's disease

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Parkinson s disease has always been considered a brain disorder. However, new research reveals a close link between the disease and certain immune cells in the blood.
Researchers from Aarhus University have taken the first step on a path which can lead to new ways of understanding and, in the long term, possibly treating this widespread disease that affects not only motor functions but also cognition and emotions.
We know that Parkinson s disease is characterized by an inflammation in the brain, and that this is crucial for the progression of the disease. But in the study, our interest has been focused on the immune cells found outside the brain, explains Marina Romero-Ramos, who is associate professor at the Department of Biomedicine at Aarhus University. ....

Eteläuomen Läi , United States , Comunidad Autonoma De Cataluna , Marina Romero Ramos , Eduardo Tolosa , Marina Romero Ramo , Nicola Pavese , Jascha Foundation , University Of Barcelona , Lundbeck Foundation , Neurology Service , Aarhus University Hospital Denmark , Aarhus University Research Foundation , Proceedings Of The National Academy Sciences , Movement Disorder Unit , Department Of Biomedicine At Aarhus University , Aarhus University Hospital , Department Of Clinical Medicine , Danish Council For Independent Research , Aarhus University , Behaviour Disorder , National Academy , Hospital Clinic , Professor Nicola Pavese , Clinical Medicine , Parkinson Disease ,

Antisense oligonucleotides as a feasible therapy to treat MECP2 duplication disorder

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Many cognitive neurodevelopmental disorders are a result of too many or too few copies of certain genes or chromosomes. To date, no treatment options exist for this class of disorders. MECP2 duplication syndrome (MDS) is one such disorder that primarily affects boys and results from a duplication spanning the methyl-CpG binding protein 2 (MECP2) locus located on the X chromosome.
A preclinical study published from the laboratory of Dr. Huda Zoghbi, professor at Baylor College of Medicine and director of the Jan and Dan Duncan Neurological Research Institute at Texas Children s Hospital, provides experimental evidence that supports the use of antisense oligonucleotides as a feasible strategy to treat MDS. The study also offers crucial insights into the pharmacodynamics of this approach, which will serve as an important guide for the design and implementation of future clinical trials for this disorder. The study appears in the journal ....

United States , Baylor College Of Medicine , Alexanderj Trostle , Sameers Bajikar , Qi Wang , Frank Rigo , Huda Zoghbi , Yehezkel Sztainberg , Paymaan Jafar Nejad , Zhandong Liu , Jianrong Tang , Yingyao Shao , Regeneron Pharmaceuticals , Chao Family Foundation , Hamill Foundation , National Institutes Of Health , Huffington Foundation , Rett Syndrome Research , Ionis Pharmaceuticals , Cockrell Family Foundation , Research Institute Of Texas , Howard Hughes Medical Institute , Baylor College , Dan Duncan Neurological Research Institute , Texas Children , Science Translational ,

Cancer 'guardian' breaks bad with one switch

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IMAGE: A model produced by scientists at Rice University shows the conformational changes caused by a mutation in the cancer-fighting p53 protein. At top left, the red box highlights the aggregation-prone.
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Credit: Kolomeisky Research Group/Rice University
HOUSTON - (March 4, 2021) - A mutation that replaces a single amino acid in a potent tumor-suppressing protein turns it from saint to sinister. A new study by a coalition of Texas institutions shows why that is more damaging than previously known.
The ubiquitous p53 protein in its natural state, sometimes called the guardian of the genome, is a front-line protector against cancer. But the mutant form appears in 50% or more of human cancers and actively blocks cancer suppressors. ....

University Of Houston , United States , Rice University , University Of Texas , David Yang , Navin Varadarajan , Aram Davtyan , Stephen Greenwell , Michelle Barton , Mohsen Fathi , Arash Saeedi , Mike Williams , Alena Klindziuk , Peter Vekilov , Jeff Falk , Michael Sherman , Kolomeisky Research Group Rice University , Rice Department Of Chemistry , National Science Foundation , Kolomeisky Research Group , University Of Texas Medical Branch At Galveston , Anatoly Kolomeisky At Rice University , Baker Institute For Public , Oregon Health Science University , Research Institute Of Texas , University Of Texas Md Anderson Cancer Center ,

AI has a specific Spider-Man 'brain cell' just like humans do

Human brains have neurons related to specific people, called grandmother cells, and now these have also been identified in artificial neural networks ....

Matthew Sparkes , Jerry Lettvin , Scientist Default Image , Spider Man , Artificial Intelligence , Neural Networks , Jennifer Aniston , Halle Berry , மேத்யூ தீப்பொறிகள் , விஞ்ஞானி இயல்புநிலை படம் , சிலந்தி மனிதன் , செயற்கை உளவுத்துறை , நரம்பியல் நெட்வொர்க்குகள் , ஜெனிபர் அனிஸ்டன் , ஹால் பெர்ரி ,

Robot "Hears" through Ear of a Locus

Tel Aviv University researchers have opened the door to sensory integrations between robots and insects: for the first time, the ear of a dead locust was. ....

Amir Ayali , Yoni Amit , Benm Maoz , Idan Fishel , Anton Sheinin , Yossi Yovel , Neta Shavil , School Of Zoology , Tel Aviv University , Sagol School Of Neuroscience , Aladar Fleischman Faculty , Sagol School , அமீர் அய்லி , யோனி அமித் , ஐடான் ஃபிஷெல் , பள்ளி ஆஃப் ஸுவாலஜீ , தொலைபேசி அவிவ் பல்கலைக்கழகம் ,