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Cellular benefits of gene therapy seen decades after treatment


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An international collaboration between Great Ormond Street Hospital, the UCL GOS Institute for Child Health and Harvard Medical School has shown that the beneficial effects of gene therapy can be seen decades after the transplanted blood stem cells has been cleared by the body.
The research team monitored five patients who were successfully cured of SCID-X1 using gene therapy at GOSH. For 3-18 years patients blood was regularly analysed to detect which cell types and biomarker chemicals were present in their blood. The results showed that even though the stem cells transplanted as part of gene therapy had been cleared by the patients, the all-important corrected immune cells, called T-cells, were still forming. ....

Nature Communications , Biomedical Research Centre , Institute For Child Health , Harvard Medical School , Great Ormond Street Hospital , Child Health , Great Ormond Street Hospital Trust , Cell Biology , Medicine Health , Immunology Allergies Asthma , Gene Therapy , இயற்கை தகவல்தொடர்புகள் , உயிர் மருத்துவ ஆராய்ச்சி மையம் , நிறுவனம் க்கு குழந்தை ஆரோக்கியம் , ஹார்வர்ட் மருத்துவ பள்ளி , நன்று ஆர்‌மஂட் தெரு மருத்துவமனை , குழந்தை ஆரோக்கியம் , நன்று ஆர்‌மஂட் தெரு மருத்துவமனை நம்பிக்கை , உயிர் வேதியியல் , செல் உயிரியல் , மருந்து ஆரோக்கியம் , நோயெதிர்ப்பு ஒவ்வாமை ஆஸ்துமா , கீந் சிகிச்சை ,

Gene therapy's cellular benefits remain decades after treatment


Gene therapy s cellular benefits remain decades after treatment
ANI |
Updated: Mar 17, 2021 23:28 IST
Washington [US], March 17 (ANI): During an international collaboration recently between Great Ormond Street Hospital, the UCL GOS Institute for Child Health, and Harvard Medical School, it was found that the beneficial effects of gene therapy can be seen decades after the transplanted blood stem cells have been cleared by the body.
The research team monitored five patients who were successfully cured of SCID-X1 using gene therapy at GOSH. For 3-18 years patients blood was regularly analysed to detect which cell types and biomarker chemicals were present in their blood. The results showed that even though the stem cells transplanted as part of gene therapy had been cleared by the patients, the all-important corrected immune cells, called T-cells, were still forming. ....

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Beneficial effects of gene therapy can be seen in SCID-X1 patients decades after treatment


Beneficial effects of gene therapy can be seen in SCID-X1 patients decades after treatment
An international collaboration between Great Ormond Street Hospital, the UCL GOS Institute for Child Health and Harvard Medical School has shown that the beneficial effects of gene therapy can be seen decades after the transplanted blood stem cells has been cleared by the body.
The research team monitored five patients who were successfully cured of SCID-X1 using gene therapy at GOSH. For 3-18 years patients blood was regularly analyzed to detect which cell types and biomarker chemicals were present in their blood. The results showed that even though the stem cells transplanted as part of gene therapy had been cleared by the patients, the all-important corrected immune cells, called T-cells, were still forming. ....

Emily Henderson , Institute For Child Health , Harvard Medical School , Great Ormond Street Hospital , Child Health , Gene Therapy , Medical School , Stem Cells , எமிலி ஹென்டர்சன் , நிறுவனம் க்கு குழந்தை ஆரோக்கியம் , ஹார்வர்ட் மருத்துவ பள்ளி , நன்று ஆர்‌மஂட் தெரு மருத்துவமனை , குழந்தை ஆரோக்கியம் , கீந் சிகிச்சை , மருத்துவ பள்ளி , தண்டு செல்கள் ,

World-leading research institutions join forces to find better treatments for pediatric diseases


World-leading research institutions join forces to find better treatments for pediatric diseases
Ahead of Rare Disease Day (28 February), four leading children s research institutions on three continents are joining forces to decipher pediatric illnesses, including rare diseases, and find better treatments.
The four pediatric hospitals Boston Children s Hospital; UCL Great Ormond Street Institute for Child Health and Great Ormond Street Hospital (London); the Murdoch Children s Research Institute with The Royal Children s Hospital (Melbourne); and The Hospital for Sick Children (SickKids) in Toronto are working together to evaluate genomic data, clinical data from patients, and scientific and medical expertise to accelerate discovery and therapeutic development. ....

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World-leading children's hospitals partner to find new treatments for pediatric diseases


 E-Mail
Ahead of Rare Disease Day (28 February), four leading children s research institutions on three continents are joining forces to decipher paediatric illnesses, including rare diseases, and find better treatments.
The four paediatric hospitals Boston Children s Hospital; UCL Great Ormond Street Institute for Child Health and Great Ormond Street Hospital (London); the Murdoch Children s Research Institute with The Royal Children s Hospital (Melbourne); and The Hospital for Sick Children (SickKids) in Toronto are working together to evaluate genomic data, clinical data from patients, and scientific and medical expertise to accelerate discovery and therapeutic development.
The partnership, known as the International Precision Child Health Partnership (IPCHiP), is the first major global collaboration around genomics and child health. The founding partners anticipate that additional institutions will join the collaboration in the future. ....

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