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Researchers provide comprehensive molecular characterization of head and neck cancers

Researchers provide comprehensive molecular characterization of head and neck cancers
In what is believed to be the most comprehensive molecular characterization to date of the most common type of head and neck cancer, researchers from the Johns Hopkins departments of pathology and oncology, the Johns Hopkins Kimmel Cancer Center, the Johns Hopkins University School of Medicine, and 18 other centers around the U.S. and Poland have clarified the contribution of key cancer-associated genes, proteins and signaling pathways in these cancers, while proposing possible new treatment avenues.
Their deep-dive investigation of HPV-negative head and neck squamous cell carcinomas (HNSCCs), described in the Jan. 7 issue of the journal ....

Hui Zhang , Johns Hopkins , Daniel Chan , Emily Henderson , Johns Hopkins Kimmel Cancer Center , Drug Administration , Johns Hopkins University School Of Medicine , Johns Hopkins University School , Cancer Cell , Principal Investigator , Biomarker Discovery , Mass Spectrometry Core , National Cancer Institute , Clinical Proteomic Tumor Analysis Consortium , Cancer Treatment , Head And Neck Cancer , Monoclonal Antibody , Vocal Cords , ஹுய் ஜாங் , ஜான்ஸ் ஹாப்கின்ஸ் , டேனியல் சான் , எமிலி ஹென்டர்சன் , ஜான்ஸ் ஹாப்கின்ஸ் கீம்மேல் புற்றுநோய் மையம் , ஜான்ஸ் ஹாப்கின்ஸ் பல்கலைக்கழகம் பள்ளி ஆஃப் மருந்து , ஜான்ஸ் ஹாப்கின்ஸ் பல்கலைக்கழகம் பள்ளி , புற்றுநோய் செல் ,

Researchers create comprehensive database of head and neck cancers

FOR IMMEDIATE RELEASE
In what is believed to be the most comprehensive molecular characterization to date of the most common type of head and neck cancer, researchers from the Johns Hopkins departments of pathology and oncology, the Johns Hopkins Kimmel Cancer Center, the Johns Hopkins University School of Medicine, and 18 other centers around the U.S. and Poland have clarified the contribution of key cancer-associated genes, proteins and signaling pathways in these cancers, while proposing possible new treatment avenues.
Their deep-dive investigation of HPV-negative head and neck squamous cell carcinomas (HNSCCs), described in the Jan. 7 issue of the journal
Cancer Cell, involved tumors from 108 patients who had not yet received cancer treatment, and 66 samples of healthy tissue surrounding the tumors. The study systematically catalogued HPV-negative HNSCC-associated proteins, phosphosites (areas where they are modified by phosphate groups) and signaling pathways, fi ....

United States , New York , Johns Hopkins University , Baylor College Of Medicine , International Institute , San Francisco , Davidj Clark , Michael Schnaubelt , Jiang Qian , Daniel Chan , Hui Zhang , Liwei Cao , Qing Kay Li , Jianbo Pan , Yuefan Wang , Johns Hopkins , Kyung Cho , Rodrigo Vargas Eguez , Zhen Zhang , Lijun Chen , National Cancer Institute , Esac Inc , Translational Breast Cancer Research Training Program , Sylvester Comprehensive Cancer Center , Pomeranian Medical University , University Of Medical Sciences ,