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IU researchers discover new potential for functional recovery after spinal cord injury

Credit: IU School of Medicine
Researchers at Indiana University School of Medicine have successfully reprogrammed a glial cell type in the central nervous system into new neurons to promote recovery after spinal cord injury revealing an untapped potential to leverage the cell for regenerative medicine.
The group of investigators published their findings March 5 in
Cell Stem Cell. This is the first time scientists have reported modifying a NG2 glia a type of supporting cell in the central nervous system into functional neurons after spinal cord injury, said Wei Wu, PhD, research associate in neurological surgery at IU School of Medicine and co-first author of the paper. ....

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Monoclonal antibody

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IMAGE: James Crowe, Jr., MD, director of the Vanderbilt Vaccine Center (VVC) and Ann Scott Carell Professor in the Departments of Pediatrics and Pathology, Microbiology and Immunology at Vanderbilt.
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Credit: Vanderbilt University Medical Center
A monoclonal antibody cocktail developed at Vanderbilt University Medical Center (VUMC) to neutralize the COVID-19 virus is effective against all known strains, or variants, of the virus, according to a report published in the journal
Nature Medicine.
That was one of the findings reported by a multi-institutional team led by researchers at Washington University School of Medicine in St. Louis.
In cell-culture studies, the researchers determined the ability of monoclonal antibodies as well as antibodies isolated from the convalescent plasma of previously infected people to neutralize highly transmissible variants of the SARS-CoV-2 virus that have arisen in the United Kingdom, South ....

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Could transforming alpha cells into beta cells treat diabetes?

Could transforming alpha cells into beta cells treat diabetes?
Written by James Kingsland on March 4, 2021 Fact checked by Rita Ponce, Ph.D.
New research in mice suggests a novel way to treat both forms of diabetes. 1130945222 Tom Werner/Getty Images
Scientists have used synthetic antibodies to block cell receptors in the liver that normally bind to glucagon, a hormone involved in increasing the amount of glucose in the blood.
The antibodies restored normal blood glucose levels in three different mouse models of diabetes.
The treatment partly worked by transforming alpha cells in the pancreas into insulin-producing beta cells.
The researchers believe that the same approach could treat type 1 and type 2 diabetes in people. ....

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Stuart Orkin receives $500,000 Gruber Genetics Prize for his groundbreaking research on genetics of inherited blood disorders

Stuart Orkin receives $500,000 Gruber Genetics Prize for his groundbreaking research on genetics of inherited blood disorders
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'No glass ceiling': Tulane doctor files discrimination lawsuit against medical school

'No glass ceiling': Tulane doctor files discrimination lawsuit against medical school
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