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$3.5 million grant supports effort led by Penn Medicine to diversify Alzheimer's research

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PHILADELPHIA Black adults are more likely than other groups to develop Alzheimer s disease or related disorders but are poorly represented in Alzheimer s disease research, including recent clinical trials. This health disparity illustrates how Black individuals can benefit from advances in the field if they had access.
This week, the Pennsylvania Department of Health s Commonwealth Universal Research Enhancement (CURE) program announced it will award a $3.5 million grant to Penn Medicine researchers and community partners to address the underrepresentation of Black adults in Alzheimer s Disease research. The grant supports the Aging Brain Cohort Dedicated to Diversity (ABCD2) study, a research and training initiative led by David Wolk, MD, a professor of Neurology in the Perelman School of Medicine at the University of Pennsylvania. Wolk is also the incoming director of the Alzheimer s Disease Research Center, and co-director of the Penn Memory Center. ....

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Need another reason to get vaccinated? It prevents sepsis, the condition that makes COVID-19 deadly

Need another reason to get vaccinated? It prevents sepsis, the condition that makes COVID-19 deadly
Marie McCullough, The Philadelphia Inquirer
April 28, 2021
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Increase your arm’s blood flow post-vaccine and swing it around.FotoDuets/Getty Images/iStockphoto
PHILADELPHIA The reason severe COVID-19 is so deadly is that it unleashes a condition called sepsis.
Sepsis occurs when an abnormal immune response to an infection damages the body’s own tissues, leading to organ failure.
Of the 26,266 people who were hospitalized with COVID-19 in Pennsylvania in the first seven months of the pandemic, about 8,000, or 31%, also were diagnosed with sepsis, according to a new report from the Pennsylvania Health Care Cost Containment Council (PHC4). ....

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What Parkinson's disease patients reveal about how art is experienced and valued

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PHILADELPHIA Art appreciation is considered essential to human experience. While taste in art varies depending on the individual, cognitive neuroscience can provide clues about how viewing art affects our neural systems, and evaluate how these systems inform our valuation of art. For instance, one study shows that viewing art activates motor areas, both in clear representations of movement, like Adam and Eve in Michelangelo s Expulsion from Paradise, and in implied movement through brush strokes, like in Franz Kline s gestural paintings.
Altered neural functioning, like that experienced in patients with Parkinson s disease, changes the way art is both perceived and valued, according to a study published recently in The ....

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Is 1 vaccine dose enough if you've had COVID-19?

The findings, published in
Science Immunology, suggest only a single vaccine dose may be needed to produce a sufficient antibody response.
Researchers found that those who did not have COVID-19 called COVID naïve did not have a full immune response until after receiving their second vaccine dose, reinforcing the importance of completing the two recommended doses for achieving strong levels of immunity.
The study provides more insight on the underlying immunobiology of mRNA vaccines, which could help shape future vaccine strategies.
“These results are encouraging for both short- and long-term vaccine efficacy, and this adds to our understanding of the mRNA vaccine immune response through the analysis of memory B cells,” says senior author E. John Wherry, chair of the department of systems pharmacology and translational therapeutics at the University of Pennsylvania and director of the Penn Institute of Immunology in the Perelman School of Medicine. ....

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Breaking News | Study suggests persons who recover from COVID-19 may need one vaccine dose

By Sola Ogundipe
Those who have had COVID-19 may only need one vaccine dose, a new study suggests People who have recovered from COVID-19 had a robust antibody response after the first mRNA vaccine dose, but a little immune benefit after the second dose, according to new research from the Penn Institute of Immunology.
The findings, published in Science Immunology, suggest only a single vaccine dose may be needed to produce a sufficient antibody response.
The team found that those who did not have COVID-19 called COVID naïve did not have a full immune response until after receiving their second vaccine dose, reinforcing the importance of completing the two recommended doses for achieving strong levels of immunity. ....

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