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The long view on COVID-19 vaccine safety and efficacy


Penn researchers weigh in on the regulatory and scientific efforts to track COVID-19 vaccines.
Between December 2020 and February 2021, three drugmakers received Emergency Use Authorizations to distribute COVID-19 vaccines. The next step is a biologics license application the technical name for full approval a process Pfizer and Moderna have already begun. Experts from Penn are keeping a close eye on these regulatory steps, as well as the reporting mechanisms involved in assessing vaccine safety. The outlook thus far seems promising. (Image: Daniel Schlud)
The mRNA vaccines for COVID-19, made by Pfizer/BioNTech and Moderna, are among the most powerful vaccines the world has ever seen. According to clinical trial data, they are more than 94% effective at preventing symptomatic disease, with real-world data bearing out that success. The other vaccine currently available in the U.S., produced by Janssen, use ....

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Doctors Weigh Pros and Cons of Prescribing Hot-Button Alzheimer's Drug


Jul 12, 2021
As physicians and health policy experts debate the merits of Aduhelm, the first new drug for Alzheimer’s disease approved in 18 years, patients want to know: “Will this medication help me and how much?”
Doctors explaining the pros and cons of Aduhelm won’t have a definitive answer. “On an individual basis, it will be absolutely impossible to predict,” said Dr. Allan Levey, director of the Goizueta Alzheimer’s Disease Research Center at Emory University.
Cognitive decline varies widely among people who have started experiencing memory and thinking problems or who are in the earliest stage of Alzheimer’s the patients in whom Aduhelm was tested, Levey noted. ....

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