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Mother's Day Advice about Mental Health from Doctor Mom

Columbia University Irving Medical Center
It’s springtime in New York City: Covid-19 vaccination rates are increasing, infection rates are slowly starting to ebb, and patients are returning to their primary care doctors’ offices.
As expected, chronic conditions like diabetes and high blood pressure have worsened for many patients, but some also display the mental health effects of chronic stress-which appears more pronounced in women and mothers.
Arthi Reddy
“It’s like the dam has broken, and everything is suddenly coming out,” says Arthi Reddy, MD, assistant professor of medicine at CUMC within the Columbia University Vagelos College of Physicians and Surgeons and an internist with Columbia’s Morningside primary care practice. ....

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New cell atlas of COVID lungs reveals why SARS-CoV-2 is deadly and different

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NEW YORK, NY (April 29, 2021) A new study is drawing the most detailed picture yet of SARS-CoV-2 infection in the lung, revealing mechanisms that result in lethal COVID-19, and may explain long-term complications and show how COVID-19 differs from other infectious diseases.
Led by researchers at Columbia University Vagelos College of Physicians and Surgeons and Herbert Irving Comprehensive Cancer Center, the study found that in patients who died of the infection, COVID-19 unleashed a detrimental trifecta of runaway inflammation, direct destruction and impaired regeneration of lung cells involved in gas exchange, and accelerated lung scarring.
Though the study looked at lungs from patients who had died of the disease, it provides solid leads as to why survivors of severe COVID may experience long-term respiratory complications due to lung scarring. ....

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Algorithm scours electronic health records to reveal hidden kidney disease

E-Mail
NEW YORK, NY Diagnosing chronic kidney disease, which is often undetected until it causes irreversible damage, may soon become automated with a new algorithm that interprets data from electronic medical records.
The algorithm, developed by researchers at Columbia University Vagelos College of Physicians and Surgeons, automatically scours a patient s electronic medical record for results of blood and urine tests and, using a mix of established equations and machine learning to process the data, can alert physicians to patients in the earliest stages of chronic kidney disease.
A study of the algorithm was published in the journal
npj Digital Medicine in April. ....

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How Does COVID Affect Mental Health?

Columbia University Irving Medical Center
Recently publicized reports of paranoia, depression, and even suicide among some COVID-19 survivors have come as no surprise to Maura Boldrini, MD, PhD, a neuroscientist and psychiatrist at Columbia University Vagelos College of Physicians and Surgeons.
Maura Boldrini
Throughout her career, Boldrini has investigated the neurobiological changes in the brain associated with cognitive and behavioral symptoms-including suicidal behavior.
“In psychiatry, we have been interested in understanding the role of neuroinflammation in psychosis, depression, and other mental health conditions,” says Boldrini.
“Previously, our group has found increased inflammation in the brains of people who die by suicide. And we’re now investigating if COVID-related inflammation can trigger suicidal thinking and other psychiatric effects.” ....

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Coronavirus does not infect the brain but still inflicts damage

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NEW YORK, NY (April 16, 2021) SARS-CoV-2, the virus that causes COVID-19, likely does not directly infect the brain but can still inflict significant neurological damage, according to a new study from neuropathologists, neurologists, and neuroradiologists at Columbia University Vagelos College of Physicians and Surgeons.
There s been considerable debate about whether this virus infects the brain, but we were unable to find any signs of virus inside brain cells of more than 40 COVID-19 patients, says James E. Goldman, MD, PhD, professor of pathology & cell biology (in psychiatry), who led the study with Peter D. Canoll, MD, PhD, professor of pathology & cell biology, and Kiran T. Thakur, MD, the Winifred Mercer Pitkin Assistant Professor of Neurology. ....

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