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Fat 'Shield' Protects Immune Cells-and Some Cancers-from Destruction


Columbia University Irving Medical Center
A newly discovered fat “shield” that prevents natural killer cells from being destroyed by their own deadly biological weapons also allows some cancer cells to evade an immune system attack, a study at Columbia University has found.
The findings, which may lead to new treatments for aggressive cancers, were reported Aug. 3 in the journal PLoS Biology by scientists in the Department of Pediatrics at Columbia University Vagelos College of Physicians and Surgeons.
A 3-dimensional model of a natural killer cell (purple) with granules (yellow) attaching to a target cell (gray). A pseudocolor scale shows differences in packing density of lipids on the natural killer cell membrane, with warmer colors indicating higher density. (Orange laboratory) ....

Reubens Carpentier , Ryu Li , Columbia University Irving Medical Center , Columbia University , Columbia University Vagelos College , University Irving Medical Center , Jordan Orange , ரூபன்ஸ் தச்சு , யூ லி , கொலம்பியா பல்கலைக்கழகம் இவிஂக் மருத்துவ மையம் , கொலம்பியா பல்கலைக்கழகம் , பல்கலைக்கழகம் இவிஂக் மருத்துவ மையம் , ஜோர்டான் ஆரஞ்சு ,

Heart problems resolve in majority of kids with COVID inflammatory syndrome


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NEW YORK, NY (July 15, 2021) Heart problems in children hospitalized with multisystem inflammatory syndrome (MIS-C) an inflammatory condition triggered by COVID were mostly gone within a few months, a new study by researchers at Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian has found.
The study published in
Pediatrics about 45 MIS-C patients is the first in North America to report on longitudinal cardiac and immunologic outcomes in children hospitalized with MIS-C.
We ve learned that COVID causes a spectrum of illness in children. Some are asymptomatic or mildly symptomatic and a small number of kids who develop MIS-C become critically ill, requiring admission to the ICU, says Kanwal M. Farooqi, MD, assistant professor of pediatrics at Columbia University Vagelos College of Physicians and Surgeons and first author of the study. It is a relief that this study shows that most of the severe heart and immunologic m ....

New York , United States , Mailman School Of Public Health , United Kingdom , Kanwalm Farooqi , Columbia University Irving Medical Center , Vagelos College Of Physicians , School Of Arts , College Of Dental Medicine , Columbia University Vagelos College Of Physicians , School Of Nursing , Columbia University Vagelos College , North America , Newyork Presbyterian Morgan Stanley Children , Multisystem Inflammatory Syndrome , Angela Chan , Rachel Weller , Pengfei Jian , Elizabeth Abrahams , Anne Ferris , Usha Krishnan , Nikhil Pasumarti , Sanghee Suh , Amee Shah , Michael Dilorenao , Philip Zachariah ,