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Cannabis sativa is an annual herbaceous flowering plant. Although used medicinally for centuries, 1, 2 it recently has experienced a significant resurgence in interest, becoming a buzzword in beauty. 3 The main reasons behind this are the richness of chemical compounds produced by the plant and the significant opening up of regulatory markets. 4 Cannabis plants contain more than 500 known compounds. In addition to phyto-cannabinoids, the plant contains saccharides, phenolic acids, flavonoids, stilbenes, lignans, fatty acids and terpenes. 5-8 Several compounds of these classes are known to impart relevant biological activities in mammalian cells, including modulating appetite, pain sensation, mood, memory, inflammation and energy metabolism. ....