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Evaluation of splenic accumulation and colocalization of immature reticulocytes and Plasmodium vivax in asymptomatic malaria: A prospective human splenectomy study

P.
All stages of
P.
vivax accumulated in the spleen at magnitudes unexplainable by replication occurring in the circulation alone, with the proportion of each stage in the spleen consistent with the duration in their lifecycle.
What do these findings mean?
Taking advantage of the large physiological splenic reservoir of immature reticulocytes, the majority of the
P.
vivax lifecycle can take place in the spleen in chronic malaria.
Chronic vivax malaria should be considered predominantly an infection of the reticulocyte-rich spleen, with secondary involvement of the intravascular compartment.
The spleen is not solely a compartment for parasite destruction and clearance. ....

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German Covid Deaths at Record; U.K. Shot Numbers: Virus Update

California Crisis Deepens; U.S. Allergic Reaction: Virus Update
Bloomberg
12/16/2020
Bloomberg News
(Bloomberg) New cases in California shattered another record as a deepening crisis threatens a shortage of intensive-care beds and medical staff. The most-populous U.S. state is struggling to control its outbreak even as most residents are under stay-at-home orders.
The first hiccups in the distribution of a Covid-19 vaccine in the U.S. included a holdup in delivering 3,900 shots to two states and the announcement that Pfizer Inc. would ship about 900,000 fewer doses next week than are set to ship this week. A health-care worker in Alaska who received the shot experienced the first known severe allergic event in the U.S. ....

South Korea , New York , United States , Hong Kong , United Kingdom , Rhode Island , New Mexico , Khorasane Janubi , Northern Ireland , South Korean , Angela Merkel , Uk Christmas Covid , Amy Rose , Gavin Newsom , Los Angeles , Wendy Magowan , Spencer Platt Getty , Andrew Cuomo , Boris Johnson , Bloomberg Hong Kong , Bloomberg Covid , Mario Tama Getty , Nadhim Zahawi , Roy Liu Bloomberg , Gabby Jones Bloomberg , Ron Desantis ,

German Virus Deaths at Record; U.K. Vaccinations: Virus Update

California Crisis Deepens; U.S. Allergic Reaction: Virus Update
Bloomberg
12/16/2020
Bloomberg News
(Bloomberg) New cases in California shattered another record as a deepening crisis threatens a shortage of intensive-care beds and medical staff. The most-populous U.S. state is struggling to control its outbreak even as most residents are under stay-at-home orders.
The first hiccups in the distribution of a Covid-19 vaccine in the U.S. included a holdup in delivering 3,900 shots to two states and the announcement that Pfizer Inc. would ship about 900,000 fewer doses next week than are set to ship this week. A health-care worker in Alaska who received the shot experienced the first known severe allergic event in the U.S. ....

United States , South Korea , New York , Hong Kong , United Kingdom , Rhode Island , New Mexico , Khorasane Janubi , Northern Ireland , South Korean , Bloomberg Hong Kong , Angela Merkel , Bloomberg Covid , Mario Tama Getty , Uk Christmas Covid , Amy Rose , Nadhim Zahawi , Gavin Newsom , Roy Liu Bloomberg , Los Angeles , Ron Desantis , Gabby Jones Bloomberg , Wendy Magowan , Spencer Platt Getty , Andrew Cuomo , Johns Hopkins University ,

German Virus Deaths, Tokyo Cases Reach Records: Virus Update

California Crisis Deepens; U.S. Allergic Reaction: Virus Update
Bloomberg
12/16/2020
Bloomberg News
(Bloomberg) New cases in California shattered another record as a deepening crisis threatens a shortage of intensive-care beds and medical staff. The most-populous U.S. state is struggling to control its outbreak even as most residents are under stay-at-home orders.
The first hiccups in the distribution of a Covid-19 vaccine in the U.S. included a holdup in delivering 3,900 shots to two states and the announcement that Pfizer Inc. would ship about 900,000 fewer doses next week than are set to ship this week. A health-care worker in Alaska who received the shot experienced the first known severe allergic event in the U.S. ....

United States , South Korea , New York , Hong Kong , Rhode Island , New Mexico , South Korean , Bloomberg Hong Kong , Angela Merkel , Bloomberg Covid , Mario Tama Getty , Uk Christmas Covid , Amy Rose , Gavin Newsom , Roy Liu Bloomberg , Los Angeles , Ron Desantis , Gabby Jones Bloomberg , Spencer Platt Getty , Andrew Cuomo , Johns Hopkins University , Us Department Of Defense , Ministry Of Manpower , International Labour Organization , Shanghai Fosun Pharmaceutical Group Co , Pfizer Inc ,