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Bagaimana Mutasi Varian Alpha Mengatasi Titik Lemahnya


Bagaimana Mutasi Varian Alpha Mengatasi Titik Lemahnya
(Ilustrasi)
01 Jul 2021 07:20
KBRN, Cambridge: Salah satu mutasi kunci yang terlihat pada SARS-CoV-2 varian Alpha - yakni penghapusan dua asam amino, H69/V70 - memungkinkan virus mengatasi celah pada pelindungnya saat berkembang, kata tim ilmuwan internasional.
SARS-CoV-2 adalah virus corona, dinamakan demikian karena protein lonjakan pada permukaannya memberikan tampilan seperti mahkota ( corona ). Protein lonjakan mengikat ACE2, reseptor protein yang ditemukan di permukaan sel dalam tubuh kita. Baik protein lonjakan dan ACE2 kemudian dibelah, memungkinkan materi genetik virus memasuki sel inang. Virus memanipulasi mesin sel inang untuk memungkinkan virus bereplikasi dan menyebar.
Saat SARS-CoV-2 membelah dan bereplika ....

Department Medicine On University , How Mutation Variant Tackle Points Weak , View As Crown , Professor Gupta , Get Together , Department Medicine , ப்ரொஃபெஸர் குப்தா , பெறு ஒன்றாக , துறை மருந்து ,

Alpha variant mutations help SARS-CoV-2 overcome evolutionary weaknesses


Alpha variant mutations help SARS-CoV-2 overcome evolutionary weaknesses
The coronavirus disease (COVID-19), caused by the pathogen severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to spread globally, infecting over 182 million people. In the process of dividing and replicating, errors in SARS-CoV-2 s genetic makeup cause it to mutate. Virus mutations can affect its transmissibility and infectiousness. Some may help the virus evade the immune system, possibly making vaccines less effective, while others have little influence.
Researchers at the University of Cambridge, MRC-University of Glasgow Centre for Virus Research, The Pirbright Institute, MRC Laboratory of Molecular Biology, and Vir Biotechnology aimed to determine how SARS-CoV-2 evades the immune system, threatening the efficacy of developed vaccines. ....

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Key mutations in Alpha variant enable SARS-CoV-2 to overcome evolutionary weak points


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SARS-CoV-2 is a coronavirus, so named because spike proteins on its surface give it the appearance of a crown (‘corona’). The spike proteins bind to ACE2, a protein receptor found on the surface of cells in our body. Both the spike protein and ACE2 are then cleaved, allowing genetic material from the virus to enter the host cell. The virus manipulates the host cell’s machinery to allow the virus to replicate and spread.
As SARS-CoV-2 divides and replicates, errors in its genetic makeup cause it to mutate. Some mutations make the virus more transmissible or more infectious, some help it evade the immune response, potentially making vaccines less effective, while others have little effect. ....

Glasgow City , United Kingdom , Bo Meng , Ravi Gupta , Laboratory Of Molecular Biology , Pirbright Institute , Melinda Gates Foundation , Cambridge Biomedical Research Centre , University Of Cambridge , National Institute For Health Research , Glasgow Centre For Virus Research , Cambridge Institute Of Therapeutic Immunology , Research Council , Department Of Medicine , Cell Reports , Glasgow Centre , Virus Research , Molecular Biology , Cambridge Institute , Therapeutic Immunology , Infectious Disease , Professor Gupta , Dalan Bailey , Medical Research Council , National Institute , Health Research ,

Key mutations in Alpha variant enable SARS-CoV-2 to overcome evolutionary weak points


University of Cambridge
One of the key mutations seen in the ‘Alpha variant’ of SARS-CoV-2 – the deletion of two amino acids, H69/V70 – enables the virus to overcome chinks in its armour as it evolves, say an international team of scientists.
SARS-CoV-2 is a coronavirus, so named because spike proteins on its surface give it the appearance of a crown (‘corona’). The spike proteins bind to ACE2, a protein receptor found on the surface of cells in our body. Both the spike protein and ACE2 are then cleaved, allowing genetic material from the virus to enter the host cell. The virus manipulates the host cell’s machinery to allow the virus to replicate and spread. ....

Glasgow City , United Kingdom , Bo Meng , Ravi Gupta , University Of Cambridge , Laboratory Of Molecular Biology , Glasgow Centre For Virus Research , Pirbright Institute , Cambridge Institute Of Therapeutic Immunology , Department Of Medicine , Cell Reports , Glasgow Centre , Virus Research , Molecular Biology , Cambridge Institute , Therapeutic Immunology , Infectious Disease , Professor Gupta , Dalan Bailey , கிளாஸ்கோ நகரம் , ஒன்றுபட்டது கிஂக்டம் , போ மெங் , ரவி குப்தா , பல்கலைக்கழகம் ஆஃப் கேம்பிரிட்ஜ் , ஆய்வகம் ஆஃப் மூலக்கூறு உயிரியல் , கிளாஸ்கோ மையம் க்கு வைரஸ் ஆராய்ச்சி ,