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Akoya (AKYA) Announces Publication of New Immunotherapy Biomarker Signature in Science, Leveraging Principles of Astronomy and Pathology

Akoya (AKYA) Announces Publication of New Immunotherapy Biomarker Signature in Science, Leveraging Principles of Astronomy and Pathology
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Janis Taube , Akoya Phenoptics , Alexander Szalay , Akoya Opal , Sneha Berry , Johns Hopkins University , Division Of Dermopathology , Bloomberg Kimmel Institute For Cancer Immunotherapy , Department Of Computer Science , Mark Foundation Center , Akoya Biosciences Inc , Spatial Biology Company , Biosciences Inc , Advanced Genomics , Bloomberg Kimmel Institute , Bloomberg Distinguished Professor , Computer Science , ஜேநிஸ் தோபே , ஜான்ஸ் ஹாப்கின்ஸ் பல்கலைக்கழகம் , ப்ளூம்பெர்க் கீம்மேல் நிறுவனம் க்கு புற்றுநோய் நோயெதிர்ப்பு சிகிச்சை , துறை ஆஃப் கணினி அறிவியல் , குறி அடித்தளம் மையம் , இடஞ்சார்ந்த உயிரியல் நிறுவனம் , உயிர் அறிவியல் இன்க் , ப்ளூம்பெர்க் கீம்மேல் நிறுவனம் , ப்ளூம்பெர்க் புகழ்பெற்ற ப்ரொஃபெஸர் ,

Astronomy meets pathology to identify predictive biomarkers for cancer immunotherapy

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IMAGE: The AstroPath platform allows for the assessment of the level of expression of a given marker on individual cells, while maintaining information on their spatial location. Shown here is.
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Credit: Seyoun Park, Ph.D.
Pairing sky-mapping algorithms with advanced immunofluorescence imaging of cancer biopsies, researchers at The Mark Foundation Center for Advanced Genomics and Imaging at Johns Hopkins University and the Bloomberg~Kimmel Institute for Cancer Immunotherapy developed a robust platform to guide immunotherapy by predicting which cancers will respond to specific therapies targeting the immune system.
A new platform, called AstroPath, melds astronomic image analysis and mapping with pathology specimens to analyze microscopic images of tumors. ....

United States , Janis Taube , Charles Roberts , Evanj Lipson , Richard Wilton , Shlomit Jessel , Harriet Kluger , Evan Lipson , Inbalb Sander , Peter Nguyen , Jose Loyola , Qingfeng Zhu , Akoya Biosciences , Michele Cleary , Robert Anders , Suzannel Topalian , Elizabethm Jaffee , Ludmila Danilova , Elizabeth Engle , Margaret Eminizer , Daphne Wang , Sneha Berry , Aleksandra Ogurtsova , Angelo Demarzo , Haiying Xu , Roberta Anders ,

Cancer News from AACR's 2021 Meeting: Targeted Therapy and Immunotherapy

Canva; Everyday Health
The annual meeting of the American Association for Cancer Research (AACR) is one of the largest cancer research meetings of its kind, bringing together a range of researchers, from those who spend their time in the lab to those who focus on patients in the clinic. The meeting atmosphere is electric even when it’s virtual. Here are five key studies that stood out during the first week of the virtual AACR meeting, held April 10–15, 2021.
Lymphoma Progression Cut in Half When Rituxan Is Paired With Aliqopa
What’s new Patients with relapsed indolent non-Hodgkin lymphoma saw a 48 percent reduced risk of progression (time without the disease advancing or death) when the targeted therapy Aliqopa (copanlisib) was used in combination with Rituxan (rituximab) versus Rituxan alone. Rituxan alone is the current standard therapy for relapses. The results, which come from a phase 3 trial known as CHRONOS-3, were announced at the AACR meeting and simu ....

New York , United States , Salt Lake City , Memorial Sloan Kettering Cancer Center , University Of Utah , Matthewj Matasar , Jessica Hassel , Aliqopa Rituxan , Patrick Forde , Anna Plym , American Association For Cancer Research , Huntsman Cancer Institute , Sidney Kimmel Comprehensive Cancer Center , Lymphoma Society , American Association , Cancer Research , Progression Cut , How Is Hodgkin Lymphoma , Punch Against Earlier Stage Lung , Bloomberg Kimmel Institute , Johns Hopkins University , Why Are , Never Smoker Getting Lung , Super Glue Protein Allows Immune System , Amp Up Response , Metastatic Ocular ,

Opdivo plus chemotherapy increases response in pre-surgery NSCLC patients

Opdivo plus chemotherapy increases response in pre-surgery NSCLC patients
Combination increases complete response rate to 24% compared to chemotherapy alone
Bristol Myers Squibb’s PD-1 inhibitor Opdivo has scored a new win in the pre-surgery, non-small cell lung cancer (NSCLC) setting.
Data presented at the virtual American Association for Cancer Research (AACR) annual meeting showcased results from the CheckMate-816 study, which evaluated Opdivo (nivolumab) plus chemotherapy in patients with early-stage NSCLC before surgery.
The primary endpoints of the study were pathological complete response (pCR), defined as no residual viable tumour in the resected lung specimen and the sampled lymph node after surgery and event-free survival (EFS). ....

United States , Patrick Forde , Bristol Myers Squibb , Johns Hopkins University , American Association For Cancer Research , Bloomberg Kimmel Institute For Cancer Immunotherapy , Sidney Kimmel Comprehensive Cancer Center , Merck Co , American Association , Cancer Research , Bloomberg Kimmel Institute , Johns Hopkins , ஒன்றுபட்டது மாநிலங்களில் , பேட்ரிக் ஃபார்ட் , பிரிஸ்டல் மைஸ் ஸ்க்விப்ப் , ஜான்ஸ் ஹாப்கின்ஸ் பல்கலைக்கழகம் , அமெரிக்கன் சங்கம் க்கு புற்றுநோய் ஆராய்ச்சி , ப்ளூம்பெர்க் கீம்மேல் நிறுவனம் க்கு புற்றுநோய் நோயெதிர்ப்பு சிகிச்சை , சிட்னி கீம்மேல் விரிவான புற்றுநோய் மையம் , மெர்க் இணை , அமெரிக்கன் சங்கம் , புற்றுநோய் ஆராய்ச்சி , ப்ளூம்பெர்க் கீம்மேல் நிறுவனம் , ஜான்ஸ் ஹாப்கின்ஸ் ,

Mutant Gene-Targeted Immunotherapy Approach Developed

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This news release, issued by Johns Hopkins Medicine, describes a novel targeted immunotherapy approach. This new approach employs bispecific antibodies to treat cancer by eliciting a Tcell response against mutated p53. The researchers used the Highly Automated Macromolecular Crystallography (AMX) and Frontier Microfocusing Macromolecular Crystallography (FMX) beamlines to characterize the molecular structure of the proteins. AMX and FMX are beamlines at the National Synchrotron Light Source II (NSLS-II) a U.S. Department of Energy (DOE) Office of Science User Facility at Brookhaven National Laboratory. NSLS-II offers a comprehensive suite of life science research capabilities. Johns Hopkins media contacts: Amy Mone, 410-614-2915, amone@jhmi.edu, or Valerie Mehl, 410-614-2916, mehlva@jhmi.edu. Brookhaven Lab media contacts: Cara Laasch, 631-344-8458, laasch@bnl.gov or Peter Genzer, 631-344-3174, genzer@bnl.gov. ....

United States , Michaelb Murphy , Shibin Zhou , Valerie Mehl , Emily Han , Nickolas Papadopoulos , Michael Hwang , Evangeline Watson , Katharine Wright , Astra Zeneca Medimmune Amplimmune , Katharinem Wright , Yana Li , Elizabeth Cook , Patricka Brown , Gabriel Ghiaur , Bristol Myers Squibb , Bert Vogelstein , Kenneth Kinzler , Suman Paul , P Aitana Azurmendi , Sandra Gabelli , Chetan Bettegowda , Chung Hsiue , Michelles Miller , Andrew Skora , Sarahr Dinapoli ,