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Selective serotonin reuptake inhibitors, and serotonin and norepinephrine reuptake inhibitors for anxiety, obsessive-compulsive, and stress disorders: A 3-level network meta-analysis

In a meta-analysis of randomized trials, Natan Pereira Gosmann and colleagues study efficacy of SSRIs and SNRIs for symptoms of anxiety, obsessive-compulsive, and stress-related disorders. ....

United States , New Zealand , Jaeger Md , Vikram Patel , Cochrane Library , International Federation Of Pharmaceutical Manufacturers Associations , Drug Administration , Harvard Medical School , Cochrane Collaboration , Costa Mda , Jaeger Mdb , Creative Commons , Finance Code , Conselho Nacional De Desenvolvimento Cient , Preferred Reporting Items , Systematic Reviews , European Clinical Trials Database , Pan African Clinical Trials Registry , International Federation , Pharmaceutical Manufacturers , Australian New Zealand Clinical Trials Registry , Social Anxiety Disorder , Anxiety Disorders , Post Traumatic Stress Disorder , Obsessive Compulsive Disorder , Medical Risk Factors ,

Vitamin D and COVID-19 susceptibility and severity in the COVID-19 Host Genetics Initiative: A Mendelian randomization study

Research Article
Vitamin D and COVID-19 susceptibility and severity in the COVID-19 Host Genetics Initiative: A Mendelian randomization study
Guillaume Butler-Laporte ,
Contributed equally to this work with:
Guillaume Butler-Laporte,
Tomoko Nakanishi
Roles
Conceptualization,
Data curation,
Formal analysis,
Investigation,
Methodology,
Software,
Validation,
Visualization,
Writing – original draft,
Writing – review & editing
Affiliations
Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada,
Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Québec, Canada
Contributed equally to this work with:
Guillaume Butler-Laporte,
Tomoko Nakanishi
Roles
Conceptualization,
Data curation,
Formal analysis,
....

United Kingdom , City Of , King College London , International Classification Of Diseases , Clinical Research Facility , Lady Davis Institute Of The Jewish , Ministry Of Health , Canadian Foundation For Innovation , Imperial College London , European Union , Public Health Agency Of Canada , Host Genetics Initiative , Research Council , Canada Excellence Research , Program For Young Researchers , Canadian Institutes Of Health Research , National Institute For Health Research , Clinical Research Scholarship , Biomedical Research Centre , Cancer Research United Kingdom , United Kingdom Biobank , Genetics Initiative , Cosetta Minelli , Creative Commons Attribution License , Canadian Institutes , Health Research ,

Association of APOE ε4 genotype and lifestyle with cognitive function among Chinese adults aged 80 years and older: A cross-sectional study

Apolipoprotein E (
APOE) ε4 is the single most important genetic risk factor for cognitive impairment and Alzheimer disease (AD), while lifestyle factors such as smoking, drinking, diet, and physical activity also have impact on cognition. The goal of the study is to investigate whether the association between lifestyle and cognition varies by
APOE genotype among the oldest old.
Methods and findings
We used the cross-sectional data including 6,160 oldest old (aged 80 years old or older) from the genetic substudy of the Chinese Longitudinal Healthy Longevity Survey (CLHLS) which is a national wide cohort study that began in 1998 with follow-up surveys every 2–3 years. Cognitive impairment was defined as a Mini-Mental State Examination (MMSE) score less than 18. Healthy lifestyle profile was classified into 3 groups by a composite measure including smoking, alcohol consumption, dietary pattern, physical activity, and body weight. ....

South Korea , United Kingdom , Carol Brayne , Chinese Longitudinal Healthy Longevity Survey , Chinese Longitudinal Healthy Longevity , University Open Research Data Platform Website , Genomics Institute , National Natural Sciences Foundation Of China , University Of Cambridge , National Bureau Of Statistics China , Research In Genomic Epidemiology , Research Ethics Committees Of Peking University , Duke University , National Key Rd Program Of China , Mini Mental State Examination , Creative Commons Attribution License , Peking University Open Research Data Platform , National Key Rd Program , National Natural Sciences Foundation , Beijing Genomics Institute , Clinical Dementia Rating , Aging Research , Genomic Epidemiology , Observational Studies , Research Ethics Committees , Peking University ,

Blood pressure-lowering treatment for the prevention of cardiovascular events in patients with atrial fibrillation: An individual participant data meta-analysis

In an individual patient data meta-analysis, Ana-Catarina Pinho-Gomes and colleagues investigate prevention of cardiovascular events with blood pressure-lowering treatment in those with and without atrial fibrillation. ....

United Kingdom , Eli Lilly , Global Challenges Research Fund Grant Ref , Oxford Martin School At University Of , National Health Service , University Of Liverpool , British Heart Foundation , Department Of Health , Research Materials , European Society Of Cardiology , Data Repository Information Coordinating Centre , American College Of Cardiology , Biomedical Research Centre , Novo Nordisk , Pinho Gomesa C , Gregory Lip , Creative Commons Attribution License , Challenges Research Fund , Grant Ref , Research Centre , Oxford Martin School , Speciality Consulting Editor , Associate Editor , Kyowa Kirin , Preferred Reporting Items , Systematic Reviews ,

Risk of prostate cancer in relatives of prostate cancer patients in Sweden: A nationwide cohort study

Risk of prostate cancer in relatives of prostate cancer patients in Sweden: A nationwide cohort study
Roles
Conceptualization,
Investigation,
Methodology,
Supervision,
Writing – original draft,
Writing – review & editing
Affiliations
Division of Preventive Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany,
Center for Primary Health Care Research, Lund University, Malmö, Sweden,
Institute of Medical Biometry and Informatics, Heidelberg University Hospital, Heidelberg, Germany
⨯
Yu Tian,
Roles
Methodology,
Writing – review & editing
Affiliations
Division of Preventive Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany,
Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany
Roles
Method ....

United States , North Carolina , Lund Regional Ethics Committee , American Joint Committee On Cancer , Swedish National Board Of Health , United States Preventive Services Task Force , American Cancer Society , Task Force , Multi Generation Register , Swedish Cancer Registry , Cancer Registry Data , International Classification , Swedish Cause , Death Register , Swedish National Board , American Joint Committee , Observational Routinely Collected , North America , Prostate Cancer Early Detection , Prostate Cancer , Cancer Risk Factors , Screening Guidelines , Medical Risk Factors , Cancers And Neoplasms , Cancer Detection And Diagnosis , Cancer Screening ,