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Special diets might boost the power of drugs to vanquish cancers

Apr. 1, 2021 , 10:10 AM
When New York City medical oncologist Vicky Makker meets a patient with endometrial cancer that has spread or recurred, she knows the outlook isn’t good. Even after radiation and drug treatments, most women with advanced disease die within 5 years.
But this spring, Makker is helping launch two clinical trials she hopes will change the picture. The drug patients will receive, called a phosphatidylinositol 3-kinase (PI3K) inhibitor, has already failed in multiple cancer trials. But the new studies are taking an unconventional tack to resurrect the drug: putting patients on a ketogenic diet, a low-carbohydrate regimen that typically involves loads of meat, cheese, eggs, and vegetables. The researchers hope the diet will render tumors more vulnerable to the drug, which blocks a growth-promoting pathway in cells. “It’s very outside of the mainstream thinking,” says Makker, a researcher at Memorial Sloan Kettering Cancer Center. ....

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Linking Metabolism, Health, and Cancer: 2020 Dr. Paul Janssen Award Symposium | The New York Academy of Sciences

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Metabolic Limitations in Cancer
All cells in the body, including cancer cells, exist in different metabolic environments, and thus have different nutritional resources available to them, said
Mathew Vander Heiden. Cancer cells have especially high metabolic needs because by definition, they proliferate doubling the mass of proteins, nucleic acids, and lipids in order to go from one cell to two. Understanding how different types of cancer cells reorganize their metabolic pathways to accomplish this feat can bring insight into the role metabolism plays in cancer therapeutics.
Tissues solve their metabolic needs differently. Metabolism in brain cells, for example, differs from that in liver cells. These differences must be reflected in the gene expression patterns of the tissues’ metabolic networks. When a cell becomes cancerous, it takes its existing metabolic network, based on its environment, and reorganizes it to support its proliferation. That’s ....

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business | Benzinga

According to Flurry Analytics, the percentage of paid apps on the App Store fell from 20 percent in 2011 to 10 percent in 2013.
That’s a 10 percent drop in two years, and the trend is likely to continue.
In general, Flurry said, people seemed to want free content even if it meant putting up. Read More. ....

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