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Roche engaged in talks with FDA for Alzheimer's drug candidate

Roche engaged in talks with FDA for Alzheimer's drug candidate
pmlive.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from pmlive.com Daily Mail and Mail on Sunday newspapers.

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Advances in Alzheimer's Disease Reported in New Issue of Brain Connectivity

Date Time
Advances in Alzheimer’s Disease Reported in New Issue of Brain Connectivity
-New advances in understanding Alzheimer’s disease based on functional connectivity and neural networks are published in a Special Issue on Alzheimer’s Disease in
Brain Connectivity, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. Click here to read the article now.
Beau Ances, Washington University in St. Louis, and coauthors, evaluated global resting-state functional connectivity signature in mutation carriers from the Dominantly Inherited Alzheimer Network. They assessed the global resting-state functional connectivity with regards to amyloid, tau, and neurodegeneration biomarkers and estimated years to symptom onset. They present their findings in the article entitled “Resting-State Function Connectivity Disruption as a Pathological Biomarker in Autosomal Dominant Alzheimer Disease.” ....

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Delores J. Anzelmo 1937-2021 | News, Sports, Jobs

May 1, 2021
AUSTINTOWN Delores J. Anzelmo, 84, passed away peacefully Thursday morning, April 29, 2021, at The Woodlands at AustinWoods, following a lengthy struggle with dementia.
Delores was born March 27, 1937, in Youngstown, the youngest of 12 children born to Harold LeRoy Hinkson and Lydia Brown Hinkson. She attended South High School and lived her life in this area.
Mrs. Anzelmo was very active and always kept busy. Before her marriage, she worked for the Robert Hall Clothing Store and for the Mahoning County Treasurer’s office. In her younger years, she was also a poll worker for the Mahoning County Board of Elections, was a member of the Austintown PTA and volunteered for the Easter Seals Amplyopia program screening in area preschools. ....

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Draining brain's debris enhances Alzheimer's therapies in mice

Date Time
Draining brain’s debris enhances Alzheimer’s therapies in mice
Experimental Alzheimer’s drugs have shown little success in slowing declines in memory and thinking, leaving scientists searching for explanations. But new research in mice has shown that some investigational Alzheimer’s therapies are more effective when paired with a treatment geared toward improving drainage of fluid – and debris – from the brain, according to a study led by researchers at Washington University School of Medicine in St. Louis.
The findings, published April 28 in the journal Nature, suggest that the brain’s drainage system – known as the meningeal lymphatics – plays a pivotal but underappreciated role in neurodegenerative disease, and that repairing faulty drains could be a key to unlocking the potential of certain Alzheimer’s therapies. ....

El Salvador , Antoine Louveau , Geraldo Farias , David Holtzman , Gretchenp Jones , Carlos Cruchaga , Jonathan Kipnis , Eli Lilly , Jasmeerp Chhatwal , Edithl Wolff , Oscar Harari , Otsuka Pharmaceuticals , School Of Medicine , Department Of Neurology , Cure Alzheimer Fund , Ed Owens Family Foundation , Alzheimer Network , Washington University School Of Medicine , Washington University , Puretech Health , Archer Foundation , Experimental Alzheimer , Washington University School , Distinguished Professor , Dominantly Inherited Alzheimer Network , National Institute ,

Grayce Ann Dolesh 1936-2021 | News, Sports, Jobs

Apr 1, 2021
POLAND Grayce Ann Dolesh, 84, of Poland, formerly of North Olmsted, passed away Tuesday morning, March 30, 2021, at the Inn at Poland Way (Memory Care Unit).
Grayce was born July 26, 1936, in East Liverpool, a daughter of the late John Arthur and Mary Alice Duffy Rumberger.
She graduated from Wellsville High School in 1954 and moved to the Cleveland area.
Grayce started her career as a dance teacher, teaching modern dance. A self-educated woman, she attended workshops in sensory motor integration with patterning and music. She was very passionate about her work helping autistic and learning disabled children. She believed early educational success started in pre-school, which motivated her to develop “Learning with a S.M.I.L.E.” Grace retired from Middleburg Early Education Center Pre-school and Lakeshore Day Camp. She enjoyed reading and loved attending the theatre with her husband and friends. ....

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