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Using iodine as catalyst to advance the sustainability of pharmaceutical syntheses


Using iodine as catalyst to advance the sustainability of pharmaceutical syntheses
Synthesizing pharmaceuticals for cancer, viral diseases, and other medical conditions is slow work. A particularly challenging chemical transformation is to start with what s known as an unactivated alkene a common molecular building block and end up with a vicinal diamine; i.e., installation of two nitrogen units into carbon carbon double bonds. The result is a chemical unit that s present in medications for influenza and colorectal cancer.
Commonly, researchers must use rare, toxic metals and harsh reaction conditions to complete this transformation. Using a more sustainable catalyst for the reaction could solve such problems. Previous research has attempted to do so, yet with only limited success. ....

United States , Satoshi Minakata , Hayato Miwa , Emily Henderson , Osaka University , Journal Of The American Chemical Society , American Chemical Society , Colorectal Cancer , ஒன்றுபட்டது மாநிலங்களில் , ஹயாடோ மிவா , எமிலி ஹென்டர்சன் , ஒசகக பல்கலைக்கழகம் , இதழ் ஆஃப் தி அமெரிக்கன் இரசாயன சமூகம் , அமெரிக்கன் இரசாயன சமூகம் , பெருங்குடல் புற்றுநோய் ,

Researchers unravel how a novel microbial small molecule is connected to dental caries development


Researchers unravel how a novel microbial small molecule is connected to dental caries development
An inter-disciplinary team of researchers led by Prof. Qian Peiyuan, Chair Professor at the Hong Kong University of Science and Technology (HKUST) s Department of Ocean Science and Division of Life Science has unraveled how a novel microbial small molecule released by Streptococcus mutans (S. mutans) - a bacterium commonly found in the human oral cavity - is connected to dental caries development using a synthetic biology approach, offering new insights to the health impact of the human oral microbiota and facilitating future research on the prevention of tooth decay. ....

Hong Kong , Qian Peiyuan , Emily Henderson , Division Of Life Science , College Of Dentistry , Department Of Ocean Science , National Institutes Of Health , University Of California At Berkeley , University Of Florida , Hong Kong University Of Science , Chair Professor , Hong Kong University , Ocean Science , Life Science , Nature Chemical Biology , National Institutes , Hansemann Professor , Tooth Decay , ஹாங் காங் , எமிலி ஹென்டர்சன் , பிரிவு ஆஃப் வாழ்க்கை அறிவியல் , கல்லூரி ஆஃப் பல் மருத்துவம் , துறை ஆஃப் கடல் அறிவியல் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா இல் பெர்க்லி , பல்கலைக்கழகம் ஆஃப் புளோரிடா ,

SARS-CoV-2 Brazilian variant may potentially escape T cell-mediated host immune responses

A team of scientists from Brazil recently explored the abilities of the UK, South African, and Brazilian variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to evade host CD8+ T cell responses induced by natural infection or vaccination. The findings reveal reduced antigenic coverage for the P.2 Brazilian lineage, indicating its ability to evade SARS-CoV-2-induced T cell responses. ....

South Africa , United Kingdom , South African , Sanchari Sinha Dutta , Coronavirus Disease Covid 19 , Sars Cov 2 , Corona Virus , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , ஒன்றுபட்டது கிஂக்டம் , சஞ்சரி சீன்ஹா தத்தா , கொரோனா வைரஸ் , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,