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FSTL3 is a prognostic biomarker in gastric cancer


DSCAM-AS1 and miR-122-5p.
Although there has been a small amount of research on FSTL3, the exact mechanism by which
FSTL3 functions as an oncogene remains unclear to date. Therefore, in the present study, we aimed to explore the molecular mechanism of
FSTL3 involvement in gastric carcinogenesis and development, and to evaluate its value as a prognostic biomarker and potential therapeutic target for GC.
Materials and Methods
Cell Culture
AGS (moderately differentiated GC cells), HGC-27 (undifferentiated GC cells), GES-1 (healthy gastric epithelial cells), and THP-1 cells (human monocytic cells) were purchased from the cell bank of the Chinese Academy of Sciences (Shanghai, China). MKN-74 and MKN-45 cells (well-differentiated and poorly differentiated GC cells, respectively) were purchased from the Japanese Collection of Research Bioresources Cell Bank. GC cells were cultured in RPMI-1640 medium (Gibco, USA, Lot: 8121248) supplemented with 10% fetal bovine ....

United States , United Kingdom , American Joint Committee On Cancer , Graphpad Software Inc , Antibody Sampler Kit Cell Signaling Technology , Aaf Association , Chinese Academy Of Sciences Shanghai , Japanese Collection Of Research Bioresources Cell Bank , Genechem Corporation Shanghai , Colorful Gene Biological Technology , National Comprehensive Cancer Network , Chinese Academy , Japanese Collection , Research Bioresources Cell , Vector Construction , Genechem Corporation , Beyotime Biotechnology , Sampler Kits , Sampler Kit , Cell Signaling Technology , Zhongshan Golden Bridge Biotechnology , Linked Immunosorbent Assay , Jiangsu Provincial Hospital , Traditional Chinese , American Joint Committee , Jiangsu Province Hospital ,

[Full text] Plakophilin-2 Promotes Lung Adenocarcinoma Development via Enhancing F


1
1Medical Oncology Department of Thoracic Cancer (2), Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang 110042, Liaoning, People’s Republic of China;
2Institute of Cancer Stem Cell, Dalian Medical University, Dalian 116044, Liaoning, People’s Republic of China
Correspondence: Rui Ma
Medical Oncology Department of Thoracic Cancer (2), Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang 110042, Liaoning, People’s Republic of China
Background: Lung cancer is one of the most aggressive tumors with high incidence and mortality, which could be classified into lung squamous cell carcinoma (LUSC) and lung adenocarcinoma (LUAD). Overexpression of Plakophilin-2 (PKP2) has been reported in multiple malignancies. However, the expression and function mechanism of PKP2 in LUAD remain illusive. ....

Eteläuomen Läi , United States , Trizol Invitrogen , People Republic Of China National Standard , Cancer Hospital Of China Medical University , Cell Bank , Cancer Hospital , China Medical University , Institutional Ethical Review Board , China Medical , Ichina National Standard , Type Culture Collection , Chinese Academy , Modified Eagle , Shanghai Genepharma , Prime Script , Cell Signaling Tech , Quantity One , Institutional Animal Care , Use Committee , Graphpad Prism , Supplementary Table , Cell Proliferation , Lung Cancer , Molecular Signatures Database , Kyoto Encyclopedia ,