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Molecular Partners AG: Molecular Partners and Novartis Report Positive Initial Results from Phase 1 Study of its COVID-19 Antiviral Therapy, Ensovibep, in Healthy Volunteers


Molecular Partners AG: Molecular Partners and Novartis Report Positive Initial Results from Phase 1 Study of its COVID-19 Antiviral Therapy, Ensovibep, in Healthy Volunteers
Predictable exposure seen post administration, confirming the expected half-life of 2-3 weeks
Global phase 2/3 registrational study planned to initiate in Q2 2021
ZURICH-SCHLIEREN, SWITZERLAND / ACCESSWIRE /
March 9, 2021 / Molecular Partners AG (SWX: MOLN), a clinical-stage biotech company that is developing a new class of custom-built protein drugs known as DARPin® therapeutics, and its collaborator Novartis, today announced initial results from its ongoing phase 1 study of its first tri-specific COVID-19 antiviral treatment, ensovibep (MP0420), in healthy volunteers.
In the placebo-controlled phase 1 study, healthy volunteers were randomized 3:1 to receive an infusion of ensovibep, or placebo, respectively. Two dosing cohorts have been fully enrolled and received a single infusion of ....

United Kingdom , Shai Biran , Nicolas Leupin , Seth Lewis , Thomas Schneckenburger , Company On Twitter At Molecularprtnrs , Molecular Partners , Molecular Partner , Ivers Lee Clinical Supply Management , Swiss Government , Co Vid , ஒன்றுபட்டது கிஂக்டம் , ஷாய் பிரன் , சேதி லெவிஸ் , மூலக்கூறு கூட்டாளர்கள் , மூலக்கூறு கூட்டாளர் , ஈவேற்ச் லீ மருத்துவ விநியோகி மேலாண்மை , சுவிஸ் அரசு , இணை வித் ,

Funnel-web spider venom may one day help save the lives of heart transplant patients


Funnel-web spider venom may one day help save the lives of heart transplant patients
Posted
TueTuesday 9
updated
WedWednesday 10
The funnel-web is Australia s most venomous spider.
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Striding along a sandy track, a group of scientists is doing something kids are warned not to do: looking for funnel-web spiders.
Leading the pack, known as the bugs-and-drugs squad , is biochemist Glenn King from the University of Queensland, who has built a career unpicking the chemical composition of Australia s venomous creatures.
He and his team have come to K gari the place you may know as Fraser Island looking for a special kind of treasure in funnel-web venom: a miracle molecule. ....

Fraser Island , Trinidad And Tobago , Sarah Scheuer , Sam Nixon , Natalie Saez , Glenn King , Victor Chang Cardiac Research Institute , University Of Queensland , Professor King , Funnel Web Spider , ஃப்ரேசர் தீவு , டிரினிடாட் மற்றும் டொபாகோ , சாரா ஸ்கீயர் , சாம் நிக்சன் , நடாலி சேஜ் , க்ளென் கிங் , வெற்றியாளர் சாங் இதய ஆராய்ச்சி நிறுவனம் , பல்கலைக்கழகம் ஆஃப் குயின்ஸ்லாந்து , ப்ரொஃபெஸர் கிங் , புனல் வலை சிலந்தி , அறுவை சிகிச்சை ,

Narrowing down on small molecular inhibitors of SARS-CoV-2 key protease


Narrowing down on small molecular inhibitors of SARS-CoV-2 key protease
A recent methodological study by researchers from the University of Luxembourg shows that the combination of virtual screening approaches, molecular dynamics simulations and machine learning can substantially facilitate small molecule screening investigations targeted at key SARS-CoV-2 viral proteins. Their findings are currently available on the
bioRxiv preprint server.
The coronavirus disease 2019 (COVID-19) pandemic, which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still a major challenge for healthcare systems and economies worldwide. And while vaccines are being rolled out all over the world, the available drug-based therapies are still lacking. ....

Ganesh Babu Manoharan , Daniel Abankwa , Enrico Glaab , University Of Luxembourg , Coronavirus Disease Covid 19 , Sars Cov 2 , Corona Virus , Health Care , In Vitro , Machine Learning , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , கணேஷ் பாபு மனோஹரன் , பல்கலைக்கழகம் ஆஃப் லக்ஸம்பர்க் , கொரோனா வைரஸ் , ஆரோக்கியம் பராமரிப்பு , இல் விட்ரோ , இயந்திரம் கற்றல் , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

Study identifies potential therapeutic target for non-alcoholic fatty liver disease


Study identifies potential therapeutic target for non-alcoholic fatty liver disease
An international team of researchers has identified the CNNM4 protein as a key regulator of magnesium in the liver and potential therapeutic target for non-alcoholic fatty liver disease, according to a study published in the
Journal of Hepatology.
Non-alcoholic steatohepatitis, a form of fatty liver disease characterized by inflammation and liver fibrosis, is associated with obesity and has a worldwide prevalence of 1.7 billion people.
Unhealthy nutritional habits and dietary imbalances are recognized as causes of many diseases. Magnesium is widely available in both plant and animal foods; most vegetables, legumes, peas, beans, and nuts are rich in magnesium, as are some seafood and spices. In recent years, there has been growing concern about inadequate magnesium intake in the general population. According to the National Health and Nutrition Examination Survey (NHANES), 79% of U. ....

Daniela Buccella , Jorge Simon , Malu Mart , Emily Henderson , Nutrition Examination Survey , National Health , Liver Disease Laboratory At Spain , York University , Liver Disease Laboratory , Enfermedades Hep , Silence Therapeutic , Oligonucleotide Discovery , New York University , Fatty Liver , Liver Disease , ஜார்ஜ் சிமோன் , மாலு மார்ட் , எமிலி ஹென்டர்சன் , ஊட்டச்சத்து தேர்வு கணக்கெடுப்பு , தேசிய ஆரோக்கியம் , கல்லீரல் நோய் ஆய்வகம் இல் ஸ்பெயின் , யார்க் பல்கலைக்கழகம் , கல்லீரல் நோய் ஆய்வகம் , ம .னம் சிகிச்சை , புதியது யார்க் பல்கலைக்கழகம் , கொழுப்பு கல்லீரல் ,