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New immune players involved in metabolic liver disease

New immune players involved in metabolic liver disease
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

Eyal David , Richard Jacqui Scheinberg , Mathias Heikenwaelder , Ido Amit , Aleksandra Deczkowska , Assaf Weiner , Lady Tania Feldmann , Wolfson Family Charitable Trust Foundation , Harryb Helmsley Charitable , Moross Integrated Cancer Center , Joycee Eisenberg Foundation , Weizmann Institute Of Science , Normane Alexander Familym Foundation , German Cancer Research Center , Penny Myers Foundation , Valeria Rosenbloom Foundation , Swiss Society Institute For Cancer Prevention Research , Adelis Foundation , Joseph Nissim Center , Thompson Family Foundation Alzheimer Disease Research Fund , Coronavirus Research Fund , Mady Dukler Fund For Cancer Research , Immunology Department , Life Sciences Research , Garvan Weizmann Partnership , Irvinge Meller Center ,

Uncovering the Anti-Myeloma Resistance Files

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Multiple myeloma (a type of blood cancer) patients live much longer today than in the past, thanks to new targeted anti-myeloma drugs, but ultimately most develop resistance to the medications, and in some the disease is resistant to therapy from the start. Weizmann Institute of Science researchers, in collaboration with physicians from
Tel Aviv Sourasky Medical Center (TASMC), have made use of extremely sensitive genomic technology to reveal genetic pathways that characterize some of the more resistant cases of multiple myeloma.
Nature Medicine, may lead to a more informed, personalized treatment for these patients, and it paves the way to using this new technology for discovering additional disease targets in other cancers. ....

Mouna Ballan , Tamar Tadmor , Yaelc Cohen , Gadi Moshe , Oren Pasvolsky , Chezi Ganzel , Meirav Laiba , Chamutal Bornstein , Baoguo Li , Eyal David , Jacqui Scheinberg , Ido Amit , Assaf Weiner , Osnat Jarchowcky Dolberg , Efrat Luttwak , Noa Lavi , Mor Zada , Irit Avivi , Olga Shvetz , Chamutal Gur , Evgeni Chubar , Iuliana Vaxman , Ofer Shpilberg , Anatoly Nemets , Anita James Rosen Foundation , Moross Integrated Cancer Center ,

Stress Response Protein Links Inflammatory Disease to Colon Cancer

Weizmann Institute of Science
The findings might help identify those at extra risk of this cancer and develop means of prevention
Inflammation promotes some of the deadliest cancers. In the colon, inflammatory bowel disease is well known to be associated with higher-than-average rates of malignancy. Nevertheless, the developing tumor is commonly diagnosed only when it has already advanced or even metastasized, possibly because the early symptoms of malignancy are often mistakenly ascribed to a flare-up of intestinal inflammation. Weizmann Institute of Science researchers have now revealed a molecular missing link between chronic gut inflammation and cancer. This revelation may help develop ways of preventing colon cancers in people with inflammatory diseases of the intestines. ....

New York , United States , Memorial Sloan Kettering Cancer Center , City Of , United Kingdom , Shimrit Mayer , Liorh Katz , Gil Friedman , Reinat Nevo , Ido Laish , Hagar Lavon , Ruth Scherz Shouval , Aliza Yemini , David Kelsen , Johna Porco , Ofra Golani , Rina Wassermann Dozorets , Rona Yaeger , Laurene Brown , Yaniv Stein , Drors Shouval , Erik Sahai , Esther Wershof , Wenhan Zhang , Meirav Pevsner Fischer , Oshrat Levi Galibov ,

How cancers hurt themselves to hurt immune cells more

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IMAGE: Ribosomes (large, dark circles) working their way down a strand of mRNA. Proteins are forming to the top and bottom. Amino acid scarcity results in ribosome logjams
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Credit: the Weizmann Institute of Science
Cancers like melanoma are hard to treat, not least because they have a varied bag of tricks for defeating or evading treatments. A combined research effort by scientists at the Weizmann Institute of Science and researchers in the Netherlands Cancer Institute in Amsterdam and the University of Oslo, Norway, shows exactly how tumors, in their battles to survive, will go so far as to starve themselves in order to keep the immune cells that would eradicate them from functioning. ....

United States , Noord Holland , Reuven Agami , Yishai Levin , Osnat Bartok , Yardena Samuels , Jean Jacques Roboh , Johanna Olweus , Karl Johan Persson , M Eh Fund , Moross Integrated Cancer Center , Joycee Eisenberg Foundation , Weizmann Institute Of Science , Ludwik Wallach Cancer Research Fund , Anniversary Lab , Brazil Tumor Bank , Weizmann Institute Molecular Genetics Department , Jacques Asseoff , Netherlands Cancer Institute , Weizmann Molecular Cell Biology Department , Institute For Cancer Diagnosis Research , Wagner Braunsberg Family Melanoma Research Fund , Erica Drake Fund , Stephen Grand Israel National Center , Rising Tide Foundation , European Research Council ,