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Trial supports shorter antibiotics for UTIs in men


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Proponents of the shorter is better philosophy for antibiotic treatment of many common bacterial infections can add another study to their list: In results published this week in
JAMA, researchers reported that, in men who had presumed symptomatic urinary tract infections (UTIs) with no fever, 7 days of antibiotics was noninferior to 14 days for resolving symptoms.
The findings are from a randomized clinical trial conducted among men at two Veterans Affairs (VA) hospitals in Minneapolis and Houston who were treated with ciprofloxacin or trimethoprim/sulfamethoxazole. No significant differences in recurrence of symptoms or adverse events occurred.
The findings support the use of a 7-day course of ciprofloxacin or trimethoprim/sulfamethoxazole as an alternative to a 14-day course for treatment of afebrile men with UTI, the study authors wrote. ....

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CDC Warns of Person-to-Person Transmission of Resistant Fungus


Since its discovery in 2009,
Candida auris has emerged as a serious threat to human health. While it can colonize the skin of healthy people without causing symptoms, the fungus also invades the bloodstreams and wounds of vulnerable people, often in health care settings, and according to the Centers for Disease Control and Prevention (CDC), more than one-third of people with these invasive infections die. Last week, the CDC announced more bad news about
C. auris: what the agency says is the first evidence that highly drug-resistant strains of the fungus are spreading from person to person. 
“If you wanted to conjure up a nightmare scenario for a drug-resistant pathogen, this would be it,” Cornelius Clancy, an infectious diseases doctor at the VA Pittsburgh Health Care System, tells ....

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Novel immunotherapy boosts long-term stroke recovery in mice


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IMAGE: These images show how regulatory T cells (Treg cells) boost the ability of microglia cells to promote the regeneration of the brain s white matter (right), compared to a sample not.
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Credit: Xiaoming Hu/University of Pittsburgh
PITTSBURGH, May 19, 2021 - Specialized immune cells that accumulate in the brain in the days and weeks after a stroke promote neural functions in mice, pointing to a potential immunotherapy that may boost recovery after the acute injury is over, University of Pittsburgh School of Medicine neurologists found.
The study, published today in the journal
Immunity, demonstrated that a population of specialized immune cells, called regulatory T (Treg) cells, serve as tissue repair engineers to promote functional recovery after stroke. Boosting Treg cells using an antibody complex treatment, originally designed as a therapy after transplantation and for diabetes, improved behavioral and cognitive function ....

United States , Sicheng Li , Ligen Shi , Lesleym Foley , Kong Chen , Qingxiu Zhang , Anastasia Gorelova , Jun Chen , Kartik Iyer , Zeyu Sun , Wei Su , Angusw Thomson , Allison Hydzik , Xuejiao Dai , Fei Xu , Donnab Stolz , T Kevin Hitchens , School Of Medicine , University Of Pittsburgh School Medicine , National Institutes Of Health , Duquesne University , National Science Foundation , Va Pittsburgh Health Care System , Us Department Of Veterans Affairs , Pittsburgh Institute Of Brain Disorders , National Institute Of Neurological Disorders ,