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Early cannabis use may increase risk of developing heart disease

Early cannabis use may increase risk of developing heart disease
Smoking cannabis when you re young may increase your risk of developing heart disease later, according to a recent University of Guelph study.
In the first study to look at specific risk indicators for cardiovascular disease (CVD) in young, healthy cannabis users, researchers found subtle but potentially important changes in heart and artery function.
Cigarette smoking is known to affect cardiovascular health, causing changes to blood vessels and the heart. Less is known about the impact of smoking cannabis on long-term CVD risk, even as use of the substance grows in Canada and abroad. Cannabis is the most commonly used recreational substance worldwide after alcohol. ....

Christian Cheung , Jamie Burr , Philip Millar , Alexandra Coates , Emily Henderson , Nutritional Sciences , Health Research Lab , Department Of Human Health , University Of Guelph , Human Performance , Human Health , Heart Disease , Arterial Stiffness , Blood Vessels , Cardiovascular Disease , ஜேமி பர் , பிலிப் மில்லர் , அலெக்சாண்ட்ரா பூச்சுகள் , எமிலி ஹென்டர்சன் , ஊட்டச்சத்து அறிவியல் , ஆரோக்கியம் ஆராய்ச்சி ஆய்வகம் , துறை ஆஃப் மனிதன் ஆரோக்கியம் , பல்கலைக்கழகம் ஆஃப் க்ல்ஃப் , மனிதன் செயல்திறன் , மனிதன் ஆரோக்கியம் , இதயம் நோய் ,

Sex differences play roles in how patients respond to brain diseases

Sex differences play roles in how patients respond to brain diseases
Men and women are impacted differently by brain diseases, like Alzheimer s disease and Parkinson s disease. Researchers are urging their colleagues to remember those differences when researching treatments and cures.
In APL Bioengineering, by AIP Publishing, University of Maryland scientists highlight a growing body of research suggesting sex differences play roles in how patients respond to brain diseases, as well as multiple sclerosis, motor neuron disease, and other brain ailments.
That is progress from just a few years ago, said Alisa Morss Clyne, director of the university s Vascular Kinetics Laboratory. ....

Alisa Morss Clyne , Emily Henderson , Vascular Kinetics Laboratory , University Of Maryland , Vascular Kinetics , Alzheimer 39s Disease , Motor Neuron Disease , Multiple Sclerosis , Parkinson 39s Disease , எமிலி ஹென்டர்சன் , வாஸ்குலர் கிநெடிக்ஸ் ஆய்வகம் , பல்கலைக்கழகம் ஆஃப் மேரிலாந்து , வாஸ்குலர் கிநெடிக்ஸ் , மோட்டார் நரம்பியல் நோய் , பல ஸ்க்லரோசிஸ் ,

Combination therapy may reduce influenza-associated morbidity and mortality

Combination therapy may reduce influenza-associated morbidity and mortality
A significant proportion of hospitalized patients with influenza develop complications of acute respiratory distress syndrome, driven by virus-induced cytopathic effects as well as exaggerated host immune response. Reporting in
The American Journal of Pathology, published by Elsevier, investigators have found that treatment with an immune receptor blocker in combination with an antiviral agent markedly improves survival of mice infected with lethal influenza and reduces lung pathology in swine-influenza-infected piglets. Their research also provides insights into the optimal timing of treatment to prevent acute lung injury.
Previously, the investigators found that an excessive influx of neutrophils, infection fighting immune cells, and the networks they create to kill pathogens, known as neutrophil extracellular traps (NETs), contribute to acute lung injury in influenza infection. Formation of ....

United States , Narasaraju Teluguakula , Emily Henderson , Veterinary Health Sciences , Oklahoma State University , American Journal , Lead Investigator , Acute Respiratory Distress Syndrome , Immune Response , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , கால்நடை ஆரோக்கியம் அறிவியல் , ஓக்லஹோமா நிலை பல்கலைக்கழகம் , அமெரிக்கன் இதழ் , வழி நடத்து புலனாய்வாளர் , எடுப்போசை சுவாச துன்பம் நோய்க்குறி , நோய் எதிர்ப்பு சக்தி பதில் , நோயியல் இயற்பியல் ,

New high-performance, safe MRI contrast agent for 3D vascular mapping

New high-performance, safe MRI contrast agent for 3D vascular mapping
Heart attack and stroke are the first and second leading causes of death in developed countries, respectively. As the disease often results in sudden death with few special prognostic symptoms, early diagnosis is very important. For this purpose, imaging techniques such as magnetic resonance imaging (MRI) are widely used to identify the narrowing or blockage of blood vessels.
In MRI, contrast agents improve the visibility of the structures such as smaller blood vessels within the body. Just as satellites or global positioning systems (GPS) give traffic congestion information, the MRI contrast agents can give accurate information of vascular conditions such as vascular blockage and stenosis. Commonly used products are the gadolinium-based contrast agents. Free gadolinium ions have high toxicity, and thus they must be administered in chelated forms. ....

Soult Ukpyolsi , South Korea , Byoung Wook , Emily Henderson , Institute For Basic Science , Yonsei University , Yonsei University College Of Medicine , Basic Science , Yonsei University College , Supramolecular Amorphous Like Iron Oxide , Blood Vessels , Heart Attack , Imaging Techniques , Magnetic Resonance Imaging , தெற்கு கொரியா , எமிலி ஹென்டர்சன் , நிறுவனம் க்கு அடிப்படை அறிவியல் , அடிப்படை அறிவியல் , இரத்தம் நாளங்கள் , இதயம் தாக்குதல் , இமேஜிங் நுட்பங்கள் , காந்த அதிர்வு இமேஜிங் , நானோ துகள்கள் ,

SARS-CoV-2 spike S1 subunit induces hypercoagulability

SARS-CoV-2 spike S1 subunit induces hypercoagulability
The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), is characterized by a range of clinical presentations. The vascular complications of the condition include a range of various coagulopathies that cause bleeding and thrombocytopenia or a hypercoagulable state. A new preprint research paper posted to the
medRxiv server describes the role of a fibrinogen-related protein in inducing these clinical features of COVID-19.
Cytokine dysregulation
Earlier research has shown a change in circulating cytokines involved in the inflammatory and coagulation pathways, indicating dysregulation of these biomarkers and the endothelium. These include fibrin(ogen), D-dimer, P-selectin and von Willebrand Factor (VWF), C-reactive protein (CRP), and other cytokines that bind to endothelial receptors. ....

Liji Thomas , Willebrand Factor , Sars Cov 2 , Corona Virus , Coronavirus Disease Covid 19 , C Reactive Protein , D Dimer , Mass Spectrometry , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , கொரோனா வைரஸ் , நிறை ஸ்பெக்ட்ரோமெட்ரி , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,