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Anti-CD7 CAR-T Therapy Yields High Response Rate in Acute Leukemia

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Donor-derived anti-CD7 chimeric antigen receptor (CAR) T-cell therapy led to complete responses in 18 of 20 patients with relapsed or refractory (r/r) T-cell acute lymphoblastic leukemia (ALL), a first-in-human clinical trial showed.
After a median follow-up of 6.3 months, 15 of the 18 responding patients remained in remission, and seven patients had undergone stem-cell transplantation (SCT). All patients developed cytokine release syndrome (CRS), which was grade 1/2 in most instances. Because the therapy involved unmanipulated T cells, a majority of patients developed graft-versus-host disease (GVHD), grade 1/2 severity in all cases. All of the patients developed severe cytopenias, which were manageable.
The results provided the basis for an ongoing phase II trial of the donor-derived anti-CD7 therapy, reported Jing Pan, MD, of the State Key Laboratory of Experimental Hematology and Beijing Boren Hospital in China, and colleagues in the ....

Jing Pan , Charles Bankhead , John Dipersio , Key Laboratory Of Experimental Hematology , Washington University In St , State Key Laboratory , Experimental Hematology , Beijing Boren Hospital , Washington University , Medpage Today , ஜிங் பான் , சார்லஸ் வங்கித் தலை , விசை ஆய்வகம் ஆஃப் சோதனை ஹீமாட்டாலஜி , வாஷிங்டன் பல்கலைக்கழகம் இல் ஸ்டம்ப் , நிலை விசை ஆய்வகம் , சோதனை ஹீமாட்டாலஜி , வாஷிங்டன் பல்கலைக்கழகம் ,

Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion

Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion
sciencemag.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencemag.org Daily Mail and Mail on Sunday newspapers.

United States , Key Laboratory Of Experimental Hematology , Ethics Committee Of Blood Disease Hospital , Enzo Life Sciences , Innovation Fund For Medical Sciences , Blood Bank Lab , Human Services , Becton Dickinson , Flight Attendant Medical Research Institute , Drug Administration , Natural Science Foundation Of Tianjin City , National Natural Sciences Foundation Of China , Ethics Committee Of Tianjin Blood Disease Hospital , Sigma Aldrich , Pall Corporation , Chinese Academy Of Medical Sciences , Prism Graphpad Software , Animal Welfare Guidelines , Boston Children , State Key Laboratory , Experimental Hematology , Animal Care , Use Committee , Ethics Committee , Blood Disease Hospital , Chinese Academy ,

Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion

Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion
sciencemag.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencemag.org Daily Mail and Mail on Sunday newspapers.

United States , Key Laboratory Of Experimental Hematology , Ethics Committee Of Blood Disease Hospital , Enzo Life Sciences , Innovation Fund For Medical Sciences , Blood Bank Lab , Human Services , Becton Dickinson , Flight Attendant Medical Research Institute , Drug Administration , Natural Science Foundation Of Tianjin City , National Natural Sciences Foundation Of China , Ethics Committee Of Tianjin Blood Disease Hospital , Sigma Aldrich , Pall Corporation , Chinese Academy Of Medical Sciences , Prism Graphpad Software , Animal Welfare Guidelines , Boston Children , State Key Laboratory , Experimental Hematology , Animal Care , Use Committee , Ethics Committee , Blood Disease Hospital , Chinese Academy ,

Delaying first spinal tap may lower risk of pediatric leukemia relapse

Corresponding author Ching-Hon Pui, M.D., chair of the St. Jude Department of Oncology, contributed to international research that helps predict and. ....

Li Zhang , Hong Kong , Jingyan Tang , Chi Kong Li , Junj Yang , Jiaoyang Cai , Jie Yu , Xiaofan Zhu , Shuhong Shen , Key Laboratory Of Experimental Hematology , National Cancer Institute , Jude Children Research Hospital , Key Laboratory , China Children Cancer Foundation , Baldrick Foundation , Shanghai Children Medical Center , Children Hospital Of Soochow University , Jude Department Of Oncology , Ching Hon Pui , Jude Children , Research Hospital , Shanghai Children , Medical Center , Chongqing Medical University , State Key Laboratory , Experimental Hematology ,

Research from Analysis Group and IHBDH Furthers Understanding of Hemophilia in China

Press release content from PR Newswire. The AP news staff was not involved in its creation.
Research from Analysis Group and IHBDH Furthers Understanding of Hemophilia in China
February 9, 2021 GMT
BOSTON, Feb. 9, 2021 /PRNewswire/ Consultants from Analysis Group, a global leader in health economics and outcomes research (HEOR), and the Institute of Hematology & Blood Diseases Hospital (IHBDH), a clinical and research institute of the Chinese Academy of Medical Sciences and Peking Union Medical College, published a pair of studies in the journal Haemophilia advancing the understanding of hemophilia in China. The study results provide critical information on patient characteristics, treatment strategies, and other clinical information needed to aid regulatory decision making, enhance the quality of care, and improve patient outcomes. ....

United States , United Kingdom , Jia Zhong , Eric Seymour , Jipan Xie , Eric Wu , Union Medical College , Key Laboratory Of Experimental Hematology , Institute Of Hematology Blood Diseases Hospital , Tianjin Laboratory Of Blood Disease Gene Therapy , National Clinical Research Center , National Reimbursement Drug List , Analysis Group , Hemophilia Treatment Center Collaboration Network Of China , Chinese Academy Of Medical Sciences , National Longitudinal Cohort Of Hematological Diseases , Blood Diseases Hospital , Chinese Academy , Medical Sciences , Peking Union Medical College , National Longitudinal Cohort , Hematological Diseases , Hemophilia Treatment Center Collaboration Network , Vice President Jipan Xie , Manager Jia Zhong , State Key Laboratory ,