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Researchers show how disgust evolved as an emotion


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Researchers show how disgust evolved as an emotion
Next time a refrigerator door opens to the smell of rotting uncooked chicken, consider the moment as an odorous encounter with the origin of disgust. That repulsion is linked to an evolved human emotion that helps avoid exposure to something sickening.
In a project that blended anthropology, biology and psychology, a University of Oregon team explored disgust by studying how Ecuador’s indigenous Shuar people, living in communities with differing levels of market integration, respond to revolting things.
The research was detailed in a paper published online Feb. 23 ahead of print in the Proceedings of the National Academy of Sciences. ....

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Watching wolf Why climate emergency threatens us all


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Watching wolf Why climate emergency threatens us all
What they teach you at Harvard Business School is that the main thing is to make sure the main thing really is the main thing. There is only one main thing: the climate emergency.
It is the main thing because it affects everything else, more than anything else. Runaway climate change won’t just kill the insurance industry, though it will. It will kill our economy, our people and our planet.
The Environment Agency plans our response to flooding and other major environmental incidents on the basis of what we call the Reasonable Worst Case scenario. The RWC for climate sounds like this: Much higher sea levels will take out most of the world’s cities, displace millions, and make much of the rest of our land surface uninhabitable or unusable. Much more extreme weather will kill more people through drought, flooding, wildfires and heatwaves than most wars have. The net effects will collapse ecosystems, sl ....

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Jubilant Therapeutics Announces Research Collaboration with Boston Children's Hospital, Harvard Medical School, to Evaluate PAD4 Inhibitors in Autoimmune/Inflammation Disease Models


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BEDMINSTER, N.J., Feb. 25, 2021 /PRNewswire/ Jubilant Therapeutics Inc., a biopharmaceutical company advancing small molecule modulators to address unmet medical needs in oncology and autoimmune diseases, today announced a collaboration with Boston Children s Hospital (https://wistar.org/) to evaluate peptidyl arginine deiminase 4 (PAD4) inhibitors under development by Jubilant Therapeutics to explore the modulation of neutrophil extracellular traps (NETosis) in preclinical models of neutrophil regulation and rheumatoid arthritis (RA).
PAD4 is an enzyme that converts arginine to citrulline in histones and is highly expressed in neutrophils. Histone citrullination has been implicated in the formation of NETs which is believed to contribute to pro-inflammation and disease progression in many autoimmune disorders including RA, fibrosis, lupus and ARDS. ....

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