Biopharming can help pioneer new treatments but cumbersome,

Biopharming can help pioneer new treatments but cumbersome, outdated regulations block innovation

Obtaining medicines from plants is not new. Aspirin was first isolated from the bark of the willow tree in the 18th century, and many other common pharmaceuticals have been purified from the world’s flora. These medicines include morphine, codeine, digitalis, the laxative Metamucil, and the anti‐​cancer drugs paclitaxel and vinblastine. A notable plant‐​derived product that has emerged from traditional Chinese medicine is artemisinin, an important treatment for malaria.Spurred by the COVID-19 pandemic, many laboratories are reorienting their research to not only look at promising compounds that occur naturally in plants, but also to manipulate plants to produce high‐​value pharmaceuticals, a practice called “biopharming.” Academics and biotech companies are using molecular genetic engineering techniques to reprogram plants—including corn, potatoes, rice, and bananas, among others—to produce significant concentrations of pharmaceuticals, including vaccines. Unfortunately, this promising research is being hindered by overregulation.Why biopharming? / Biopharming’s great promise lies in using genetic engineering techniques to make old plants do radically new things, often more cheaply than is possible with non‐​plant platforms. The technology is similar to that used to insert genes into non‐​plant organisms, as has been done for decades. For instance, the gene that expresses the human insulin gene was inserted into the bacterium E. coli, and the genetically modified bacteria have been the source of that critical drug since 1982. Similarly, genetically engineered baker’s yeast that contains the gene for a surface protein of the hepatitis B virus has been the source of hepatitis B vaccine since 1986.

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