Latest update Public Health England (PHE) has identified 38 cases of COVID-19 which genomic sequencing has shown to feature a specific set of mutations which are currently being referred to as lineage B.1.525. The set of mutations includes the E484K spike protein mutation, which is present on a number of other variants of concern and variants under investigation. This variant has been designated a Variant Under Investigation (VUI) and will be referred to as VUI202102/03. The variant has been detected in other countries, including Nigeria, Denmark and Canada. Cases are geographically dispersed across England. Enhanced contact tracing and genomic sequencing is underway to monitor the situation as it develops.